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【产品名称】：Anti- Caspase-3抗体,*活化半胱胺酸蛋白酶蛋白3抗体  

【产品编号】：BYK-0081R

【产品规格】：0.1ml/0.2ml

【产品价格】：询价（电询或客服）

【抗体来源】：Rabbit OR Mouse or Goat

【产品用途】：科研实验，用于ELISA实验、免疫组化实验，WB实验，IF实验等，可，索取产品说明书！
【性    状】： Lyophilized or Liquid
【浓    度】： 1mg/1ml 
【亚    型】： IgG

【贮    存】： 贮存于-20℃.

【相关标记】：HRP  Biotin  Gold  RBITC  AP  FITC  Cy3  Cy5  Cy5.5  Cy7 PE  PE-Cy3  PE-CY5  PE-CY5.5  PE-CY7  APC  Alexa Fluor 350   Alexa Fluor 488    Alexa Fluor 555     Alexa Fluor 647

【产品别名】：Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1.

【产品介绍】：The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. 
Reacts with Caspase-3 subunit p17 and precursor.

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