HER-2/neu基因检测试剂盒 荧光原位杂交法

 广州健仑生物科技​有限公司 

本司长期供应尼古丁（可替宁）检测试剂盒，其主要品牌包括美国NovaBios、广州健仑、广州创仑等进口产品，国产产品，试剂盒的实验方法是胶体金方法。

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

 人类该基因定位于染色体17q12，其编码产物为185kD的跨膜精蛋白p185，由1255个氨基酸组成，720—987位属于酪氨酸激酶区。Her-2/neu蛋白是具有酪氨酸蛋白激酶活性跨膜糖蛋白，是EGFR家族成员之一。

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以下是我司出售的部分FISH产品：

The human gene is located on chromosome 17q12, and its encoded product is 185kD transmembrane protamine p185, which is composed of 1255 amino acids. The 720 to 987 belongs to the tyrosine kinase region. Her-2/neu protein is a tyrosine protein kinase active transmembrane glycoprotein and is one of the members of the EGFR family.The human genes of C-erbB-2 and Her-2 are discovered because they are similar to retrovirus V - erbB-2. After Coussens L and Schechte AL, Neu, Her-2, C-erbB-2 were sequenced and chromosomal location analysis proved that they were the same gene.

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Her-2/neu protein by extracellular ligand binding region, a single transmembrane region and intracellular protein tyrosine kinase domain is composed of three parts, because has not yet found the ligand can bind directly to Her-2/neu protein. It mainly through other members with family including EGFR (HERl/erbBI), HER3/ erbB3. HER4/erbB4 forms an isooligomer and combines with the respective ligands. The Her-2/neu protein is often the preferred mate of the isomer, and the activity is often stronger than the other iso - two - polymer. When binding to the ligand, the activity of tyrosine kinase is activated mainly by causing the receptor dimerization and the autophosphorylation of the tyrosine kinase region in the cytoplasm.
It has been shown that overexpression of HRE-2 can potentially activate EGFR signaling pathways, and also promote EGFR mediated transformation and tumor formation.

HER-2/neu基因检测试剂盒 荧光原位杂交法

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 

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【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室

【企业文化宣传】HER-2/neu基因检测试剂盒 荧光原位杂交法

It is important to reveal that non-bacteria are the means by which Streptomyces platensis protects itself, as other bacteria may also acquire this method and become resistant to bacteria.
The relationship between microorganisms and humans is complex. In almost all supermarkets, antibacterial soap and probiotic yogurt can be bought at the same time. Although some bacteria can make life bacteria, but the number of non-bacterial bacteria in the human body is actually a positive bacteria to maintain our health foundation. Experiments in mice have shown that adding probiotics can reduce intestinal bacteria, but also promote the immune cells in the blood against harmful bacteria infection.
A study published in the March 12, 2014 issue of Cell Host & Microbe showed that gut beneficial bacteria are essential for the development of innate immune cells, especially as the body's first line of defense against bacterial microbial invaders Blood white blood cells.
In addition to the blood circulation system, spleen and bone marrow are also stored immune cells. Researchers tested the immune cells in different mice using germ-free mice without gut bacteria in the gut and positive bacteria with positive bacterial gut flora. As a result, it was found that sterilized rat immune cells (including macrophages, monocytes, and neutrophils) showed less germ than normal bacteria.
Sterile mice also contain fewer granulocytes and monocyte progenitor cells, stem like cells, which can eventually differentiate into several different types of mature immune cells. Natural immune cells of the spleen are also flawed.
It is noteworthy that these gut microbes have far more effects on immune cells than the gut environment in which they live, and microorganisms can affect immune cells in places such as blood, spleen and bone marrow, where the presence of positive bacteria is none Bacteria
The researchers infected mice with Listeria monocytogenes to study the susceptibility of bacterial germs to sterile mice with immunocytopenia. Results Positive bacterial mice were injected with bacteria, the mice quickly returned to health, but the asexual mice died. Inoculating positive bacterial gut flora into germ-free mice then increases the number of immune cells in the body and also protects against Listeria infection.
In addition, before injecting positive bacteria with Listeria, the broad-spectrum antibiotics were used to kill the harmful bacteria and positive bacterial flora in mice. As a result, these mice were not able to combat Listeria infection.