品牌
生产厂家厂商性质
广州市所在地
美国Seracare百日咳杆菌IGM（Bordela Pertussis IgM）
广州健仑生物科技有限公司
广州健仑长期供应各种生物原料，主要代理品牌：美国Seracare、西班牙Certest、美国Fuller等等。
主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。
其中常见的有：弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。
美国Seracare百日咳杆菌IGM（Bordela Pertussis IgM）
我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
欢迎咨询
欢迎咨询2042552662
【Seracare产品介绍】
编号 | 英文名称 | 中文名称 |
JL-FA-01 | Amebiasis (AME) | 阿米巴病 |
JL-FA-02 | Allergens, Rast scores | 过敏原，放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质 |
JL-FA-03 | Allergens, Rast scores negative | 过敏原，放射性过敏原吸收实验阴性 |
JL-FA-04 | Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis | 抗环瓜氨酸肽抗体 |
JL-FA-05 | ASCA Saccharomyces Cerevi | 人抗酿酒酵母抗体（ASCA） |
JL-FA-06 | Aspergillis | 麴菌病 |
JL-FA-07 | Beta 2 Glycoprotein | β2糖蛋白 |
JL-FA-08 | Beta 2 Glycoprotein IgM | β2糖蛋白 IGM |
JL-FA-09 | Bordela Pertussis | 百日咳杆菌 |
JL-FA-10 | Bordela Pertussis IgM | 百日咳杆菌 IGM |
JL-FA-11 | C-ANCA | C-抗中性粒细胞胞浆抗体（ANCA) |
JL-FA-12 | Cardiolipin | 心肌磷脂 |
JL-FA-13 | Cardiolipin IgA | 心肌磷脂 IGA |
JL-FA-14 | Cardiolipin IgG | 心肌磷脂 IGG |
JL-FA-15 | Cardiolipin IgM | 心肌磷脂 IGM |
JL-FA-16 | Cerebral Spinal Fluid | 脑脊髓液 |
JL-FA-17 | Chagas | 恰加斯病/南美锥虫 |
JL-FA-18 | Chlamydia | 衣原体 |
JL-FA-19 | Chlamydia IgA | 衣原体IGA |
JL-FA-20 | Chlamydia IgG | 衣原体IGG |
JL-FA-21 | Chlamydia IgM | 衣原体IGM |
JL-FA-22 | Chlamydia Neg | 衣原体阴性 |
JL-FA-23 | Clotting Factor C3 | 凝固因子C3 |
JL-FA-24 | Clotting Factor C4 | 凝固因子C4 |
JL-FA-25 | Coccidiodes | 球孢菌 |
JL-FA-26 | Cytomegalovirus (CMV) Neg | 巨细胞病毒抗体阴性 |
JL-FA-27 | CMV IgG | 巨细胞病毒 IGG阳性 |
JL-FA-28 | CMV IgM VCA | 巨细胞病毒 IGM 阳性 |
JL-FA-29 | C-Reactive Protein (CRP) | C-反应蛋白质 |
JL-FA-30 | Dengue Fever | 登革热 |
JL-FA-31 | Dengue Fever IgM | 登革热 IGM |
JL-FA-32 | DS (Double Stranded) DNA | 双链脱氧核糖核酸 |
JL-FA-33 | EBNA (Epstein-Barr nuclear antigen) IgG | EB病毒核抗原 IGG |
JL-FA-34 | EBNA (Epstein-Barr nuclear antigen) IgM | EB病毒核抗原 IGM |
JL-FA-35 | Epstein Barr Virus (EBV) Negative Plasma | EB病毒阴性血浆 |
JL-FA-36 | Epstein Barr Virus (EBV) EA IgM | EB病毒早期抗原 IGM |
JL-FA-37 | Epstein Barr Virus (EBV) VCA IgM | EB病毒壳蛋白 IGM |
JL-FA-38 | Epstein Barr Virus (EBV) EA IgG | EB病毒早期抗原 IGG |
JL-FA-39 | EMA (Endomysial Antibodies) | 肌内膜 |
JL-FA-40 | Gliadin | 麸蛋白,麦醇溶蛋白,麦胶蛋白 |
JL-FA-41 | Gliadin IgG | 麦醇溶蛋白 IGG |
JL-FA-42 | Gliadin IgA | 麦醇溶蛋白 IGA |
JL-FA-43 | Glomerular Basement Membrane (GBMA) | 肾小球基底膜病 |
JL-FA-44 | Helicobacter pylori IgA | 幽门螺旋杆菌IGA |
JL-FA-45 | Helicobacter pylori IgG | 幽门螺旋杆菌IGG |
JL-FA-46 | Helicobacter pylori IgM | 幽门螺旋杆菌IGM |
JL-FA-47 | Helicobacter pylori Negative | 幽门螺旋杆菌阴性 |
JL-FA-48 | Helicobacter pylori Positive Plasma | 幽门螺旋杆菌阴性血浆 |
JL-FA-49 | Hepatitis A Virus (HAV) Pos. Plasma | 甲型肝炎病毒阳性血浆 |
JL-FA-50 | Hepatitis A Virus (HAV) IgM | 甲型肝炎病毒IGM |
JL-FA-51 | Hepatitis B Core (HBc) IgG | 乙型肝炎病毒核心 IGG |
JL-FA-52 | Hepatitis B Core (HBc) IgM | 乙型肝炎病毒核心 IGM |
JL-FA-53 | Anti Hbe (Antibody to HBV antigen) | 乙肝抗体 |
JL-FA-54 | Hepatitis Delta Virus | 丁型肝炎病毒 |
JL-FA-55 | HBeAg (HBV e antigen) | 乙肝 E抗原 |
JL-FA-56 | anti-HBs (HBV surface antibody) | 乙肝表面抗体 |
JL-FA-57 | Hepatitis B (HBsAg) "Chronic" | 乙型肝炎（乙肝表面抗原）“慢性病 |
JL-FA-58 | HBsAg (HBV surface antigen) Serum | 乙肝表面抗原血清 |
JL-FA-59 | HBsAg (AD) | 乙肝表面抗原（AD） |
JL-FA-60 | HBsAg (AY) | 乙肝表面抗原（AY） |
JL-FA-61 | HBV Positive Plasma | 乙肝阳性血浆 |
JL-FA-62 | HBV DNA Plasma | 乙肝DNA血浆 |
JL-FA-63 | HBV DNA Serum | 乙肝DNA血清 |
JL-FA-64 | HBV DNA type A | A型 乙肝DNA |
JL-FA-65 | HBV DNA type B | B型 乙肝DNA |
JL-FA-66 | HBV DNA type C | C型 乙肝DNA |
JL-FA-67 | HBV DNA type D | D型 乙肝DNA |
JL-FA-68 | HBV DNA type E | E型 乙肝DNA |
JL-FA-69 | HBV DNA type F | F型 乙肝DNA |
JL-FA-70 | HBV Antibody HCV Antibody Plasma CO-INFECTED | 乙肝和丙肝联合感染血浆 |
JL-FA-71 | HCV (Hepatitis C Virus) Antibody | 丙型肝炎抗体 |
JL-FA-72 | HCV Core Antigen Positive | 丙肝核心抗原 阳性 |
JL-FA-73 | HCV RNA PLASMA Genotype 1 | 基因1型丙肝RNA 血浆 |
JL-FA-74 | HCV RNA PLASMA Genotype 2 | 基因2型丙肝RNA 血浆 |
JL-FA-75 | HCV RNA PLASMA Genotype 3 | 基因3型丙肝RNA 血浆 |
JL-FA-76 | HCV RNA PLASMA Genotype 4 | 基因4型丙肝RNA 血浆 |
JL-FA-77 | HCV RNA PLASMA Genotype 5 | 基因5型丙肝RNA 血浆 |
JL-FA-78 | HCV RNA PLASMA Genotype 6 | 基因6型丙肝RNA 血浆 |
JL-FA-79 | HCV Riba single band | 丙肝免疫印迹单波段 |
JL-FA-80 | HCV RIBA Pos. (multiple bands) | 丙肝免疫印迹阳性多波段 |
JL-FA-81 | HCV Negative | 丙肝阴性 |
JL-FA-82 | HCV RNA Pos (quantitative) | 丙肝RNA阳性（定量） |
JL-FA-83 | Hepatitis E | 戊型肝炎 |
JL-FA-84 | Herpes Simplex Virus (HSV)1/2 Positive Plasma | 单纯性疱疹病毒1/2阳性血浆 |
JL-FA-85 | Herpes Simplex Virus (HSV) 1 Negative Plasma | 单纯性疱疹病毒1 阴性血浆 |
JL-FA-86 | Herpes Simplex Virus (HSV) 1 IgG | 单纯性疱疹病毒1 IGG |
JL-FA-87 | Herpes Simplex Virus (HSV 1) IgM | 单纯性疱疹病毒1 IGM |
JL-FA-88 | Herpes Simplex Virus (HSV) 2 IgG | 单纯性疱疹病毒2 IGG |
JL-FA-89 | Herpes Simplex Virus (HSV) 2 IgM | 单纯性疱疹病毒2 IGG |
JL-FA-90 | Histone | 组蛋白 |
JL-FA-91 | Human Anti Mouse Ab (HAMA) | 人抗鼠抗体 |
JL-FA-92 | Human immunodeficiency virus (HIV) 1 Neg | HIV I 阴性 |
JL-FA-93 | anti Human immunodeficiency virus (HIV) 1 Plasma | 抗HIV I 血浆 |
JL-FA-94 | anti Human immunodeficiency virus (HIV) 1 Serum | 抗HIV I 血清 |
JL-FA-95 | anti Human immunodeficiency virus (HIV) 2 Western Blot Tested | 抗HIV 2 免疫印迹 |
JL-FA-96 | anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+) | 抗HIV 1/2 2 HIV阳性 |
JL-FA-97 | Human immunodeficiency virus (HIV) Ag | HIV抗原 |
JL-FA-98 | HIV RNA (quantitative) Plasma | HIV RNA 定量血浆 |
JL-FA-99 | HIV RNA (quantitative) Serum | HIV RNA 定量血清 |
JL-FA-100 | HIV1 Subtype A | HIV1 亚型A |
JL-FA-101 | HIV1 Subtype B | HIV1 亚型B |
JL-FA-102 | HIV1 Subtype C | HIV1 亚型C |
JL-FA-103 | HIV1 Subtype D | HIV1 亚型D |
JL-FA-104 | HIV1 Subtype E | HIV1 亚型E |
JL-FA-105 | HIV1 Subtype F | HIV1 亚型F |
JL-FA-106 | HIV1 Subtype G | HIV1 亚型G |
JL-FA-107 | HIV1 Subtype H | HIV1 亚型H |
JL-FA-108 | HIV1 Subtype J | HIV1 亚型J |
JL-FA-109 | HIV1 Subtype K | HIV1 亚型K |
JL-FA-110 | HIV1 Group O | HIV1 亚型O |
JL-FA-111 | Human immunodeficiency virus (HIV) 2 Antibody Plasma | HIV 2 抗体血浆 |
JL-FA-112 | Human immunodeficiency virus (HIV) 2 Antibody Serum | HIV 2 抗体血清 |
JL-FA-113 | HPV (Human Papiloma Virus) Negative | 人乳状瘤病毒HPV阴性 |
JL-FA-114 | HPV (Human Papiloma Virus) Positive | 人乳状瘤病毒HPV阳性 |
JL-FA-115 | Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED | HIV 抗体 HCV |
JL-FA-116 | Human T-cell Lymphotropic Virus (HTLV) I/II | 人嗜T淋巴细胞病毒(HTLV) I/II |
JL-FA-117 | Human T-cell Lymphotropic Virus (HTLV) I | 人嗜T淋巴细胞病毒(HTLV) I |
JL-FA-118 | Human T-cell Lymphotropic Virus (HTLV) II | 人嗜T淋巴细胞病毒(HTLV) II |
JL-FA-119 | Jo-1 | 多发性肌炎抗原JO-1 |
JL-FA-120 | IgE < 5,000 Ku/L | IgE < 5,000 Ku/L |
JL-FA-121 | Legionella | 军团杆菌属 |
JL-FA-122 | Leptospira | 军团杆菌属 |
JL-FA-123 | Lyme Disease | 莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生 |
JL-FA-124 | Lyme IgG | 莱姆(氏)病 IGG |
JL-FA-125 | Lyme IgM | 莱姆(氏)病 IGM |
JL-FA-126 | Lyme Disease Neg | 莱姆(氏)病 阴性 |
JL-FA-127 | Malaria | 疟疾 |
JL-FA-128 | Mononucleosis (infectious) | 单核细胞增多症（有传染性的） |
JL-FA-129 | Mononucleosis Negative | 单核细胞增多症阴性 |
JL-FA-130 | Measles Negative | 麻疹 阴性 |
JL-FA-131 | Measles IgG | 麻疹 IGG |
JL-FA-132 | Measles IgM | 麻疹 IGM |
JL-FA-133 | Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL) | 微粒体抗甲状腺过氧化物酶抗体 |
JL-FA-134 | Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma | 微粒体抗甲状腺过氧化物酶抗体 |
JL-FA-135 | Anti-mitochondrial antibody (AMA) | 抗线粒体抗体 |
JL-FA-136 | Multiple Sclerosis | 多发性硬化症 |
JL-FA-137 | Mumps IgG | 流行性腮腺炎 IGG |
JL-FA-138 | Mumps Ab IgM | 流行性腮腺炎抗体 IGM |
JL-FA-139 | Mumps Antibody Negative Plasma | 流行性腮腺炎抗体阴性血浆 |
JL-FA-140 | Mumps Antibody Negative Serum | 流行性腮腺炎抗体阴性血清 |
JL-FA-141 | Myeloma Plasma | 骨髓瘤血浆 |
JL-FA-142 | Myeloma IgA | 骨髓瘤IGA |
JL-FA-143 | Myeloma IgE | 骨髓瘤IGE |
JL-FA-144 | Myeloma IgG | 骨髓瘤IGG |
JL-FA-145 | Myeloma IgM | 骨髓瘤IGM |
JL-FA-146 | Mycoplasma | 支原体 |
JL-FA-147 | Mycoplasma Negative | 支原体阴性 |
JL-FA-148 | Mycoplasma IgG | 支原体IGG |
JL-FA-149 | Mycoplasma IgM | 支原体IGM |
JL-FA-150 | Mycoplasma PCR | 支原体PCR |
JL-FA-151 | Normal Human Plasma | 正常人血浆 |
JL-FA-152 | Normal Human Serum | 正常人血清 |
JL-FA-153 | Nuclear Antibody Centromere | 核抗体着丝粒 |
JL-FA-154 | Nuclear Antibody, Speckled ANA | 核抗体，斑点抗核抗体 |
JL-FA-155 | Nuclear Antibody, Nucleolar ANA | 核抗体,核仁抗核抗体 |
JL-FA-156 | Nuclear Antibody, Homogeneous ANA | 核抗体，同质抗核抗体 |
JL-FA-157 | Nuclear Antiobody, Speckled. (ANA) Negative | 核抗体，斑点。抗核抗体阴性 |
JL-FA-158 | P-ANCA (associated neutrophil cytoplasmic antibodies) | 相关的嗜中性粒细胞胞浆抗体 |
JL-FA-159 | Parietal Cell Antibody (PCA) | 胃)壁细胞抗体 |
JL-FA-160 | Parvo positive plasma | 细小病毒阳性血浆 |
JL-FA-161 | Parvo IgM | 细小病毒 IGM |
JL-FA-162 | Parvo IgG | 细小病毒 IGG |
JL-FA-163 | Parvo Negative Plasma | 细小病毒阴性血浆 |
JL-FA-164 | Parvo DNA positive | 细小病毒 DNA 阳性 |
JL-FA-165 | Phospholipid Positive Plasma | 磷脂阳性血浆 |
JL-FA-166 | Prothrombin | 凝血酶原,凝血因子 |
JL-FA-167 | Rheumatoid Factor (RF) <1000 IU/mL | 类风湿因子<1000 IU/mL |
JL-FA-168 | Rheumatoid Factor (RF) 1001-2000 IU/mL | 类风湿因子1001-2000 IU/mL |
JL-FA-169 | Rheumatoid Factor (RF) 2001-4000 IU/mL | 类风湿因子 2001-4000 IU/mL |
JL-FA-170 | Rheumatoid Factor (RF) 4001-5000 IU/mL | 类风湿因子 4001-5000 IU/mL |
JL-FA-171 | Rheumatoid Factor (RF) >5000 IU/mL | 类风湿因子>5000 IU/mL |
JL-FA-172 | Ribonucleoprotein (RNP) Positive | 核糖核蛋白阳性 |
JL-FA-173 | Rubella Chimeric | 风疹 |
JL-FA-174 | Rubella Negative | 风疹阴性 |
JL-FA-175 | Rubella IgG | 风疹IGG |
JL-FA-176 | Rubella IgM | 风疹IGM |
JL-FA-177 | Rubeola Negative Plasma | 风疹阴性血浆 |
JL-FA-178 | Rubeola IgG | 风疹IGG |
JL-FA-179 | Scleroderma (Scl-70) Pos | 胶原沉着病,硬皮病,硬皮症 阳性 |
JL-FA-180 | Scleroderma (Scl-70) Negative | 硬皮病阴性 |
JL-FA-181 | Sickle Cell Fresh Whole Blood | 镰刀形红细胞新鲜全血 |
JL-FA-182 | Smith (SM) | 抗Smith抗体阳性血清（SLE的特征性抗体） |
JL-FA-183 | SMITH RNP | 抗RNP抗体阳性血清（SLE的特征性抗体） |
JL-FA-184 | Smooth Muscle (ASMA) | 抗平滑肌抗体阳性血清 |
JL-FA-185 | Sjogren syndrome antigen A (SSA) Positive | 舍格伦综合征或干燥综合征抗原A 阳性 |
JL-FA-186 | Sjogren syndrome antigen B (SSB) Positive | 舍格伦综合征抗原B 阳性 |
JL-FA-187 | Sjogren syndrome antigen B (SSB) Negative | 舍格伦综合征抗原B阴性 |
JL-FA-188 | Streptolysin O Ab (ASO) | 链球菌溶血素O抗体 |
JL-FA-189 | Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma | 梅毒（梅毒-快速血浆反应）阳性血浆 |
JL-FA-190 | Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma | 梅毒（梅毒-快速血浆反应）阴性血浆 |
JL-FA-191 | Syphilis/ATA/T. pallidum IgG | 梅毒ATA/T，苍白球IGG |
JL-FA-192 | Syphilis/ATA/T. pallidum IgM | 梅毒ATA/T，苍白球IGM |
JL-FA-193 | Systemic Lupus Erythematosus (SLE) Positive | 全身性红斑狼疮阳性 |
JL-FA-194 | Systemic Lupus Erythematosus (SLE) Negative | 全身性红斑狼疮阴性 |
JL-FA-195 | TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL) | 甲状腺球蛋白/甲状腺过氧化物酶阳性 |
JL-FA-196 | TG/TPO Negative | 甲状腺球蛋白/甲状腺过氧化物酶阴性 |
JL-FA-197 | TTG (Tissue Transglutaminase) | 组织转谷氨酰胺酶 |
JL-FA-198 | TTG (Tissue Transglutaminase) IgA | 组织转谷氨酰胺酶 IGA |
JL-FA-199 | ToRCH (Toxo, Rubella, CMV, HSV) Positive | 优生优育（弓形虫，风疹，巨细胞，单胞）阳性 |
JL-FA-200 | ToRCH (Toxo, Rubella, CMV, HSV) Negative | 优生优育（弓形虫，风疹，巨细胞，单胞）阴性 |
JL-FA-201 | Toxoplasmosis (Toxo) | 弓形虫病 |
JL-FA-202 | Toxoplasmosis (Toxo) IgG | 弓形虫病IGG |
JL-FA-203 | Toxoplasmosis (Toxo) IgM | 弓形虫病IGM |
JL-FA-204 | Thyroglobulin (TG) Positive Plasma | 甲状腺球蛋白阳性血浆 |
JL-FA-205 | Thyroglobulin (TG) Negative | 甲状腺球蛋白阴性 |
JL-FA-206 | Varicella-Zoster Virus (VZV) Negative | 水痘-带状疱疹病毒阴性 |
JL-FA-207 | Varicella-Zoster Virus (VZV) IgG | 水痘-带状疱疹病毒IGG |
JL-FA-208 | Varicella-Zoster Virus (VZV) IgM | 水痘-带状疱疹病毒IGM |
JL-FA-209 | West Nile Virus (WNV) | 西尼罗河脑炎病毒 |
JL-FA-210 | West Nile Virus (WNV) IgM | 西尼罗河脑炎病毒IGM |
美国Seracare百日咳杆菌IGM（Bordela Pertussis IgM）
进而，研究人员充分整合TALEN和HDAdV作为基因组靶向修饰工具的*优势，发展出一种新型高效的疾病基因矫正载体HDAdV。HDAdV同时具有TALEN的特异性基因组切割和HDAdV的高导入效率及精确的大片段同源重组效率。同一个HDAdV可有效涵盖HBB基因座上所有可能包含的遗传突变，因此可被广泛应用于包括镰刀形细胞贫血症和地中海贫血症在内的不同种类的血红蛋白疾病的基因修复。实验结果表明，HDAdV介导的基因修复比单独使用TALEN和CPRISPR在效率上约高数十倍，可被应用于不同种类的人类致病基因突变的靶向矫正。
该研究打消了干细胞和再生医学研究领域针对疾病基因靶向修复安全性的忧虑;同时，新型基因矫正载体的问世也将有助于加速干细胞临床转化的步伐。Cell Stem Cell杂志同期发表的题为“What’s Changed with Genome Editing?”的Preview评论说：“这些发现将无疑鼓舞将基因组靶向编辑技术进一步应用于疾病研究和临床治疗”。
该工作得到科技部、基金委及中科院干细胞与再生医学战略先导专项等资助。
在细胞核中DNA缠绕着称之为组蛋白的特殊蛋白质。通常情况下，组蛋白使得DNA紧密包装，阻止了基因表达和DNA复制，后两者是细胞生长和分裂的必要条件。为了让这些至关重要的功能得以执行，需要由一种叫做乙酰辅酶A(acetyl-CoA)的关键分子提供乙酰基，附着到组蛋白上对其进行修饰。这种附着使得DNA松弛,允许DNA复制和基因表达。这一称作为“DNA表观遗传调控”的机制对于正常的功能，以及心脏衰竭或癌症等常见疾病均极为重要。然而直到现在，对于细胞核生成组蛋白乙酰化所需的乙酰辅酶A的机制仍不清楚。
在医学系博士后研究人员Gopinath Sutendra和Evangelos Michelakis教授的下，这一研究小组发现过去被认为仅定位在线粒体内的一种酶: 丙酮酸脱氢酶复合体(PDC)实际上可以进入到细胞核中，完成它在线粒体中所做的事情：生成乙酰辅酶A。在线粒体中时，PDC利用我们饮食中的碳水化合物来生成乙酰辅酶A是为了产生能量。而在细胞核中，PDC生成乙酰辅酶A是为了实现组蛋白乙酰化。
Sutendra说：“一种酶从一个细胞器跳跃到另一个细胞器中，这真是*，我们的结果相当的惊人。我们原本想检测线粒体中乙酰辅酶A的水平和PDC,因为我们认为它们存在于那里。然而偶然地我们同时得到了分离出的细胞核，我们在细胞核中看到了PDC。因此我们提出了疑问，‘PDC在那里做什么?’一切由此开始。”
美国Seracare百日咳杆菌IGM（Bordela Pertussis IgM）
我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、食品安全、化妆品检测、药物滥用检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
想了解更多的产品及服务请扫描下方二维码：
【公司名称】 广州健仑生物科技有限公司
【市场部】 杨永汉
【】
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室
Furthermore, the researchers fully integrated the unique advantages of TALEN and HDAdV as genomics-targeted modifiers to develop a new and efficient disease-modifying gene, HDAdV. HDAdV has both TALEN specific genomic cleavage and HDAdV high import efficiency and accurate large fragment homologous recombination efficiency. The same HDAdV effectively covers all possible genetic mutations in the HBB locus and therefore can be widely used for gene repair of different kinds of hemoglobin diseases including sickle cell anemia and thalassemia. The experimental results show that HDAdV-mediated gene repair is about a dozen times more efficient than TALEN and CPRISPR alone and can be used to target different types of human pathogenic mutations.
The study dispelled concerns about the safety of disease-targeted gene repair in stem cell and regenerative medicine research. Meanwhile, the advent of a new gene correction vector will also help accelerate the clinical transformation of stem cells. Preview comments from Cell Stem Cell, titled "What's Changed with Genome Editing?", Said: "These findings will undoubtedly encourage the further application of genome-targeted editing techniques in disease research and clinical treatment."
The work was funded by the Ministry of Science and Technology, the Commission and the CAS Stem Cell and Regenerative Medicine Strategy Pilot Project.
In the nucleus, DNA wraps around special proteins called histones. Typically, histones make DNA tightly packed, preventing gene expression and DNA replication, both of which are necessary for cell growth and division. To enable these crucial functions to be performed, it is necessary to provide an acetyl group from a key molecule called acetyl-CoA, which is attached to the histone to modify it. This attachment relaxes the DNA, allowing DNA replication and gene expression. This mechanism, called "DNA epigenetic regulation," is crucial for normal function and for common diseases such as heart failure or cancer. Until now, however, the mechanism of acetyl-CoA required for acetylation of histones in nucleus formation remained unclear.
Led by Gopinath Sutendra and Evangelos Michelakis, postdoctoral researchers in the Department of Medicine, the team found that the enzyme, pyruvate dehydrogenase complex (PDC), an enzyme previously thought to locate only within the mitochondria, can actually enter the nucleus , To accomplish what it does in the mitochondria: generate acetyl-CoA. In mitochondria, PDC uses the carbohydrates in our diet to produce acetyl-CoA for energy production. In the nucleus, PDC produces acetyl-CoA for histone acetylation.
Sutendra said: "It's really unheard of that an enzyme jumps from one organelle to another organelle, and we're pretty alarming.We originally wanted to test acetylcholine-coenzyme A levels and PDC in the mitochondria, because we think they're there. Occasionally, however, we got both separated nuclei, and we saw the PDC in the nucleus, so we asked the question, 'Where does the PDC do?'
