麴菌病/曲霉属质控品Aspergillis
麴菌病/曲霉属质控品Aspergillis

美国Seracare麴菌病/曲霉属质控品Aspergillis

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具体成交价以合同协议为准
2022-11-29 20:48:09
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广州健仑生物科技有限公司

广州健仑生物科技有限公司

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产品简介

美国Seracare麴菌病/曲霉属质控品Aspergillis 抗原抗体 标准品 需要了解美国Seracare的产品可以,本质控品由广州健仑生物供应。

详细介绍

美国Seracare麴菌病/曲霉属质控品Aspergillis

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料,主要代理品牌:美国Seracare、西班牙Certest、美国Fuller等等。

主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。

其中常见的有:弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。

美国Seracare麴菌病/曲霉属质控品Aspergillis

我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

欢迎咨询

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Seracare产品介绍】

编号

英文名称

中文名称

JL-FA-01

Amebiasis (AME)

阿米巴病

JL-FA-02

Allergens, Rast scores

过敏原,放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质

JL-FA-03

Allergens, Rast scores negative

过敏原,放射性过敏原吸收实验阴性

JL-FA-04

Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis

抗环瓜氨酸肽抗体

JL-FA-05

ASCA Saccharomyces Cerevi

人抗酿酒酵母抗体(ASCA)

JL-FA-06

Aspergillis

麴菌病

JL-FA-07

Beta 2 Glycoprotein

β2糖蛋白

JL-FA-08

Beta 2 Glycoprotein  IgM

β2糖蛋白 IGM

JL-FA-09

Bordela Pertussis

百日咳杆菌

JL-FA-10

Bordela Pertussis IgM

百日咳杆菌 IGM

JL-FA-11

C-ANCA

C-抗中性粒细胞胞浆抗体(ANCA)

JL-FA-12

Cardiolipin

心肌磷脂

JL-FA-13

Cardiolipin IgA

心肌磷脂 IGA

JL-FA-14

Cardiolipin IgG

心肌磷脂 IGG

JL-FA-15

Cardiolipin IgM

心肌磷脂 IGM

JL-FA-16

Cerebral Spinal Fluid

脑脊髓液

JL-FA-17

Chagas

恰加斯病/南美锥虫

JL-FA-18

Chlamydia

衣原体

JL-FA-19

Chlamydia IgA

衣原体IGA

JL-FA-20

Chlamydia IgG

衣原体IGG

JL-FA-21

Chlamydia IgM

衣原体IGM

JL-FA-22

Chlamydia Neg

衣原体阴性

JL-FA-23

Clotting Factor C3

凝固因子C3

JL-FA-24

Clotting Factor C4

凝固因子C4

JL-FA-25

Coccidiodes

球孢菌

JL-FA-26

Cytomegalovirus (CMV) Neg

巨细胞病毒抗体阴性

JL-FA-27

CMV IgG

巨细胞病毒 IGG阳性

JL-FA-28

CMV IgM VCA

巨细胞病毒 IGM 阳性

JL-FA-29

C-Reactive Protein (CRP)

C-反应蛋白质

JL-FA-30

Dengue Fever

登革热

JL-FA-31

Dengue Fever IgM

登革热 IGM

JL-FA-32

DS (Double Stranded) DNA

双链脱氧核糖核酸

JL-FA-33

EBNA (Epstein-Barr nuclear antigen) IgG

EB病毒核抗原 IGG

JL-FA-34

EBNA (Epstein-Barr nuclear antigen) IgM

EB病毒核抗原 IGM

JL-FA-35

Epstein Barr Virus (EBV) Negative Plasma

EB病毒阴性血浆

JL-FA-36

Epstein Barr Virus (EBV) EA IgM

EB病毒早期抗原 IGM

JL-FA-37

Epstein Barr Virus (EBV) VCA IgM

EB病毒壳蛋白  IGM

JL-FA-38

Epstein Barr Virus (EBV) EA IgG

EB病毒早期抗原 IGG

JL-FA-39

EMA (Endomysial Antibodies)

肌内膜

JL-FA-40

Gliadin

麸蛋白,麦醇溶蛋白,麦胶蛋白

JL-FA-41

Gliadin IgG

麦醇溶蛋白  IGG

JL-FA-42

Gliadin IgA

麦醇溶蛋白 IGA

JL-FA-43

Glomerular Basement Membrane (GBMA)

肾小球基底膜病

JL-FA-44

Helicobacter pylori IgA

幽门螺旋杆菌IGA

JL-FA-45

Helicobacter pylori IgG

幽门螺旋杆菌IGG

JL-FA-46

Helicobacter pylori IgM

幽门螺旋杆菌IGM

JL-FA-47

Helicobacter pylori Negative

幽门螺旋杆菌阴性

JL-FA-48

Helicobacter pylori Positive Plasma

幽门螺旋杆菌阴性血浆

JL-FA-49

Hepatitis A Virus (HAV) Pos. Plasma

甲型肝炎病毒阳性血浆

JL-FA-50

Hepatitis A Virus (HAV) IgM

甲型肝炎病毒IGM

JL-FA-51

Hepatitis B Core (HBc) IgG

乙型肝炎病毒核心 IGG

JL-FA-52

Hepatitis B Core (HBc) IgM

乙型肝炎病毒核心 IGM

JL-FA-53

Anti Hbe (Antibody to HBV antigen)

乙肝抗体

JL-FA-54

Hepatitis Delta Virus

丁型肝炎病毒

JL-FA-55

HBeAg (HBV e antigen)

乙肝 E抗原

JL-FA-56

anti-HBs (HBV surface antibody)

乙肝表面抗体

JL-FA-57

Hepatitis B (HBsAg) "Chronic"

乙型肝炎(乙肝表面抗原)“慢性病

JL-FA-58

HBsAg (HBV surface antigen) Serum

乙肝表面抗原血清

JL-FA-59

HBsAg (AD)

乙肝表面抗原(AD)

JL-FA-60

HBsAg (AY)

乙肝表面抗原(AY)

JL-FA-61

HBV Positive Plasma

乙肝阳性血浆

JL-FA-62

HBV DNA Plasma

乙肝DNA血浆

JL-FA-63

HBV DNA Serum

乙肝DNA血清

JL-FA-64

HBV DNA type A

 A型 乙肝DNA

JL-FA-65

HBV DNA type B

 B型 乙肝DNA

JL-FA-66

HBV DNA type C

 C型 乙肝DNA

JL-FA-67

HBV DNA type D

 D型 乙肝DNA

JL-FA-68

HBV DNA type E

 E型 乙肝DNA

JL-FA-69

HBV DNA type F

 F型 乙肝DNA

JL-FA-70

HBV Antibody HCV Antibody Plasma CO-INFECTED

乙肝和丙肝联合感染血浆

JL-FA-71

HCV (Hepatitis C Virus) Antibody

丙型肝炎抗体

JL-FA-72

HCV Core Antigen Positive

丙肝核心抗原 阳性

JL-FA-73

HCV RNA PLASMA Genotype 1

基因1型丙肝RNA 血浆

JL-FA-74

HCV RNA PLASMA Genotype 2

基因2型丙肝RNA 血浆

JL-FA-75

HCV RNA PLASMA Genotype 3

基因3型丙肝RNA 血浆

JL-FA-76

HCV RNA PLASMA Genotype 4

基因4型丙肝RNA 血浆

JL-FA-77

HCV RNA PLASMA Genotype 5

基因5型丙肝RNA 血浆

JL-FA-78

HCV RNA PLASMA Genotype 6

基因6型丙肝RNA 血浆

JL-FA-79

HCV Riba single band

丙肝免疫印迹单波段

JL-FA-80

HCV RIBA Pos. (multiple bands)

丙肝免疫印迹阳性多波段

JL-FA-81

HCV Negative

丙肝阴性

JL-FA-82

HCV RNA Pos (quantitative)

丙肝RNA阳性(定量)

JL-FA-83

Hepatitis E

戊型肝炎

JL-FA-84

Herpes Simplex Virus (HSV)1/2 Positive Plasma

单纯性疱疹病毒1/2阳性血浆

JL-FA-85

Herpes Simplex Virus (HSV) 1 Negative Plasma

单纯性疱疹病毒1 阴性血浆

JL-FA-86

Herpes Simplex Virus (HSV) 1 IgG

单纯性疱疹病毒1 IGG

JL-FA-87

Herpes Simplex Virus (HSV 1) IgM

单纯性疱疹病毒1 IGM

JL-FA-88

Herpes Simplex Virus (HSV) 2 IgG

单纯性疱疹病毒2 IGG

JL-FA-89

Herpes Simplex Virus (HSV) 2 IgM

单纯性疱疹病毒2 IGG

JL-FA-90

Histone

组蛋白

JL-FA-91

Human Anti Mouse Ab (HAMA)

人抗鼠抗体

JL-FA-92

Human immunodeficiency virus (HIV) 1 Neg

HIV  I 阴性

JL-FA-93

anti Human immunodeficiency virus (HIV) 1 Plasma

抗HIV  I 血浆

JL-FA-94

anti Human immunodeficiency virus (HIV) 1 Serum

抗HIV  I 血清

JL-FA-95

anti Human immunodeficiency virus (HIV) 2 Western Blot Tested

抗HIV  2 免疫印迹

JL-FA-96

anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)

抗HIV 1/2 2  HIV阳性

JL-FA-97

Human immunodeficiency virus (HIV) Ag

HIV抗原

JL-FA-98

HIV RNA (quantitative) Plasma

HIV RNA 定量血浆

JL-FA-99

HIV RNA (quantitative) Serum

HIV RNA 定量血清

JL-FA-100

HIV1 Subtype A

HIV1  亚型A

JL-FA-101

HIV1 Subtype B

HIV1  亚型B

JL-FA-102

HIV1 Subtype C

HIV1  亚型C

JL-FA-103

HIV1 Subtype D

HIV1  亚型D

JL-FA-104

HIV1 Subtype E

HIV1  亚型E

JL-FA-105

HIV1 Subtype F

HIV1  亚型F

JL-FA-106

HIV1 Subtype G

HIV1  亚型G

JL-FA-107

HIV1 Subtype H

HIV1  亚型H

JL-FA-108

HIV1 Subtype J

HIV1  亚型J

JL-FA-109

HIV1 Subtype K

HIV1  亚型K

JL-FA-110

HIV1 Group O

HIV1  亚型O

JL-FA-111

Human immunodeficiency virus (HIV) 2 Antibody Plasma

HIV 2 抗体血浆

JL-FA-112

Human immunodeficiency virus (HIV) 2 Antibody Serum

HIV 2 抗体血清

JL-FA-113

HPV (Human Papiloma Virus) Negative

人乳状瘤病毒HPV阴性

JL-FA-114

HPV (Human Papiloma Virus) Positive

人乳状瘤病毒HPV阳性

JL-FA-115

Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED

HIV 抗体  HCV

JL-FA-116

Human T-cell Lymphotropic Virus (HTLV) I/II

人嗜T淋巴细胞病毒(HTLV) I/II

JL-FA-117

Human T-cell Lymphotropic Virus (HTLV) I

人嗜T淋巴细胞病毒(HTLV) I

JL-FA-118

Human T-cell Lymphotropic Virus (HTLV) II

人嗜T淋巴细胞病毒(HTLV) II

JL-FA-119

Jo-1

多发性肌炎抗原JO-1

JL-FA-120

IgE < 5,000 Ku/L

IgE < 5,000 Ku/L

JL-FA-121

Legionella

军团杆菌属

JL-FA-122

Leptospira

军团杆菌属

JL-FA-123

Lyme Disease

莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生

JL-FA-124

Lyme IgG

莱姆(氏)病 IGG

JL-FA-125

Lyme IgM

莱姆(氏)病 IGM

JL-FA-126

Lyme Disease Neg

莱姆(氏)病 阴性

JL-FA-127

Malaria

疟疾

JL-FA-128

Mononucleosis (infectious)

单核细胞增多症(有传染性的)

JL-FA-129

Mononucleosis Negative

单核细胞增多症阴性

JL-FA-130

Measles Negative

麻疹 阴性

JL-FA-131

Measles IgG

麻疹 IGG

JL-FA-132

Measles IgM

麻疹  IGM

JL-FA-133

Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)

微粒体抗甲状腺过氧化物酶抗体

JL-FA-134

Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma

微粒体抗甲状腺过氧化物酶抗体

JL-FA-135

Anti-mitochondrial antibody (AMA)

抗线粒体抗体

JL-FA-136

Multiple Sclerosis

多发性硬化症

JL-FA-137

Mumps IgG

流行性腮腺炎 IGG

JL-FA-138

Mumps Ab IgM

流行性腮腺炎抗体 IGM

JL-FA-139

Mumps Antibody Negative Plasma

流行性腮腺炎抗体阴性血浆

JL-FA-140

Mumps Antibody Negative Serum

流行性腮腺炎抗体阴性血清

JL-FA-141

Myeloma Plasma

骨髓瘤血浆

JL-FA-142

Myeloma IgA

骨髓瘤IGA

JL-FA-143

Myeloma IgE

骨髓瘤IGE

JL-FA-144

Myeloma IgG

骨髓瘤IGG

JL-FA-145

Myeloma IgM

骨髓瘤IGM

JL-FA-146

Mycoplasma

支原体

JL-FA-147

Mycoplasma Negative

支原体阴性

JL-FA-148

Mycoplasma IgG

支原体IGG

JL-FA-149

Mycoplasma IgM

支原体IGM

JL-FA-150

Mycoplasma PCR

支原体PCR

JL-FA-151

Normal Human Plasma

正常人血浆

JL-FA-152

Normal Human Serum

正常人血清

JL-FA-153

Nuclear Antibody Centromere

核抗体着丝粒

JL-FA-154

Nuclear Antibody, Speckled ANA

核抗体,斑点抗核抗体

JL-FA-155

Nuclear Antibody, Nucleolar ANA

核抗体,核仁抗核抗体

JL-FA-156

Nuclear Antibody, Homogeneous ANA

核抗体,同质抗核抗体

JL-FA-157

Nuclear Antiobody, Speckled. (ANA) Negative

核抗体,斑点。抗核抗体阴性

JL-FA-158

P-ANCA (associated neutrophil cytoplasmic antibodies)

相关的嗜中性粒细胞胞浆抗体

JL-FA-159

Parietal Cell Antibody (PCA)

胃)壁细胞抗体

JL-FA-160

Parvo positive plasma

细小病毒阳性血浆

JL-FA-161

Parvo IgM

细小病毒 IGM

JL-FA-162

Parvo IgG

细小病毒 IGG

JL-FA-163

Parvo Negative Plasma

细小病毒阴性血浆

JL-FA-164

Parvo DNA positive

细小病毒 DNA 阳性

JL-FA-165

Phospholipid Positive Plasma

磷脂阳性血浆

JL-FA-166

Prothrombin

凝血酶原,凝血因子

JL-FA-167

Rheumatoid Factor (RF) <1000 IU/mL

类风湿因子<1000 IU/mL

JL-FA-168

Rheumatoid Factor (RF) 1001-2000 IU/mL

类风湿因子1001-2000 IU/mL

JL-FA-169

Rheumatoid Factor (RF) 2001-4000 IU/mL

类风湿因子 2001-4000 IU/mL

JL-FA-170

Rheumatoid Factor (RF) 4001-5000 IU/mL

类风湿因子 4001-5000 IU/mL

JL-FA-171

Rheumatoid Factor (RF) >5000 IU/mL

类风湿因子>5000 IU/mL

JL-FA-172

Ribonucleoprotein (RNP) Positive

核糖核蛋白阳性

JL-FA-173

Rubella Chimeric

风疹

JL-FA-174

Rubella Negative

风疹阴性

JL-FA-175

Rubella IgG

风疹IGG

JL-FA-176

Rubella IgM

风疹IGM

JL-FA-177

Rubeola Negative Plasma

风疹阴性血浆

JL-FA-178

Rubeola IgG

风疹IGG

JL-FA-179

Scleroderma (Scl-70) Pos

胶原沉着病,硬皮病,硬皮症 阳性

JL-FA-180

Scleroderma (Scl-70) Negative

硬皮病阴性

JL-FA-181

Sickle Cell Fresh Whole Blood

镰刀形红细胞新鲜全血

JL-FA-182

Smith (SM)

抗Smith抗体阳性血清(SLE的特征性抗体)

JL-FA-183

SMITH RNP

抗RNP抗体阳性血清(SLE的特征性抗体)

JL-FA-184

Smooth Muscle (ASMA)

抗平滑肌抗体阳性血清

JL-FA-185

Sjogren syndrome antigen A (SSA) Positive

舍格伦综合征或干燥综合征抗原A 阳性

JL-FA-186

Sjogren syndrome antigen B (SSB) Positive

舍格伦综合征抗原B 阳性

JL-FA-187

Sjogren syndrome antigen B (SSB) Negative

舍格伦综合征抗原B阴性

JL-FA-188

Streptolysin O Ab (ASO)

链球菌溶血素O抗体

JL-FA-189

Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma

梅毒(梅毒-快速血浆反应)阳性血浆

JL-FA-190

Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma

梅毒(梅毒-快速血浆反应)阴性血浆

JL-FA-191

Syphilis/ATA/T. pallidum IgG

梅毒ATA/T,苍白球IGG

JL-FA-192

Syphilis/ATA/T. pallidum IgM

梅毒ATA/T,苍白球IGM

JL-FA-193

Systemic Lupus Erythematosus (SLE) Positive

全身性红斑狼疮阳性

JL-FA-194

Systemic Lupus Erythematosus (SLE) Negative

全身性红斑狼疮阴性

JL-FA-195

TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)

甲状腺球蛋白/甲状腺过氧化物酶阳性

JL-FA-196

TG/TPO Negative

甲状腺球蛋白/甲状腺过氧化物酶阴性

JL-FA-197

TTG (Tissue Transglutaminase)

组织转谷氨酰胺酶

JL-FA-198

TTG (Tissue Transglutaminase) IgA

组织转谷氨酰胺酶 IGA

JL-FA-199

ToRCH (Toxo, Rubella, CMV, HSV) Positive

优生优育(弓形虫,风疹,巨细胞,单胞)阳性

JL-FA-200

ToRCH (Toxo, Rubella, CMV, HSV) Negative

优生优育(弓形虫,风疹,巨细胞,单胞)阴性

JL-FA-201

Toxoplasmosis (Toxo)

弓形虫病

JL-FA-202

Toxoplasmosis (Toxo) IgG

弓形虫病IGG

JL-FA-203

Toxoplasmosis (Toxo) IgM

弓形虫病IGM

JL-FA-204

Thyroglobulin (TG) Positive Plasma

甲状腺球蛋白阳性血浆

JL-FA-205

Thyroglobulin (TG) Negative

甲状腺球蛋白阴性

JL-FA-206

Varicella-Zoster Virus (VZV) Negative

水痘-带状疱疹病毒阴性

JL-FA-207

Varicella-Zoster Virus (VZV) IgG

水痘-带状疱疹病毒IGG

JL-FA-208

Varicella-Zoster Virus (VZV) IgM

水痘-带状疱疹病毒IGM

JL-FA-209

West Nile Virus (WNV)

西尼罗河脑炎病毒

JL-FA-210

West Nile Virus (WNV) IgM

西尼罗河脑炎病毒IGM

美国Seracare

老年群体抗原抗体益增多痴呆患者的现象对现行的医疗体系是个巨大的考验。阿尔茨海默病(AD)、帕金森综合症(PD),以及额颞区痴呆(Frontotemporal dementia)患者的脑部病灶都存有异常的大量不溶蛋白质,会导致神经元的大量丢失。为了减少这些不溶蛋白质造成的长期损伤,凋亡的细胞和聚集的蛋白质必须被有效地降解或清除,这正是被称为小神经胶质细胞(Microglia)这种特殊的吞噬细胞的作用所在。小神经胶质细胞仅存于中央神经系统,属于先天性免疫体系的一部分,它就像大脑的卫生检查员,确保垃圾被及时清除,以免这些垃圾威胁到周边正常细胞。
该研究发现,TREM2 基因能调节小神经胶质细胞的吞噬效率。正常情况下,TREM2嵌入小神经胶质细胞的外膜,膜以外的功能域能识别死亡细胞留下的碎片。然而,TREM2基因的特定突变会干扰蛋白质合成过程中蛋白链的正常折叠,使之在运送到小神经胶质细胞外膜之前就被降解了,导致小神经胶质细胞处理细胞碎片的效率降低,继而那些有毒的不溶蛋白质以及凋亡的细胞在大脑聚集,并触发炎症反应,导致神经元受损。
研究人员表示,这项新发现明确了多种不同脑部疾病的共同机理,并为延缓那些已经表征痴呆症状的患者的治疗指明了道路。
膜蛋白对于光合作用、视觉等功能至关重要。它们还是细胞的看门人,能决定什么可能会通过细胞膜,也帮助从细胞膜外部输入养料和将内部垃圾输出。由于这些多重角色,它们构成了很大一部分的药物靶点。虽然它们的功能很明确,但是关于它们如何折叠的信息却远远落后于球状蛋白质。
Wolynes及其同事使用原始的基因组信息,来预测氨基酸链将如何通过遵循阻力zui小的途径(取决于链上每个残基相关的能量),折叠成为功能蛋白质。一个蛋白质越接近于其功能性“原始”状态,它就会越稳定。Wolynes的开创性理论生动地将这种能量描绘成一个漏斗。
为了检测他们的计算机模型,研究人员将它们与X射线晶体学获得的真实蛋白质结构进行比较。大量的结构对球状折叠的蛋白质是可用的,这些蛋白漂浮在体内,执行生命*的任务。
但直到zui近几年,我们已经很难获得跨膜蛋白的相似结构,因为要提取它们用于成像,同时又不会破坏它们,难度非常的大。zui近有研究人员利用一种去垢剂洗掉目的蛋白上的大多数膜,Wolynes称:“它在蛋白质周围留下一个脂肪层,但是却给出一种涂层,可使整个分子在后来形成晶格。”

美国Seracare

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Antibiotics in the elderly population increases the number of patients with dementia on the current medical system is a huge test. Alzheimer's disease (AD), Parkinson's disease (PD), and brain lesions in patients with frontotemporal dementia have abnormally large amounts of insoluble proteins that result in substantial neuronal loss. In order to reduce the long-term damage caused by these insoluble proteins, apoptotic cells and aggregated proteins must be effectively degraded or cleared, which is what is known as the special phagocyte called microglia. Microglia, which reside only in the central nervous system and are part of the innate immune system, acts like a brain health inspector to ensure that rubbish is removed in time to prevent the rubbish from threatening the surrounding normal cells.
The study found that, TREM2 gene can regulate the phagocytic efficiency of microglia. Under normal circumstances, TREM2 embedded in the outer membrane of microglial cells, the membrane outside the domain can identify the debris left by dead cells. However, certain mutations in the TREM2 gene interfere with the normal folding of protein chains during protein synthesis, degrading them before they are delivered to the outer microglia, resulting in a reduction in the efficiency of microglial cells handling cell debris, Then those toxic insoluble proteins and apoptotic cells accumulate in the brain and trigger an inflammatory response, leading to neuronal damage.
The researchers said the new findings pinpoint common causes of many different brain diseases and point the way to delaying the treatment of those who already have symptoms of dementia.
Membrane proteins are essential for photosynthesis, vision and other functions. They are also gatekeepers to cells that determine what may pass through the cell membrane and also help to input nourishment from the exterior of the cell membrane and to export internal junk. Due to these multiple roles, they constitute a large part of the drug target. Although their function is clear, the information about how they fold is far behind globular proteins.
Wolynes and colleagues use the raw genomic information to predict how amino acid chains will fold into functional proteins by following the pathway of least resistance, depending on the energy associated with each residue on the chain. The closer a protein is to its functional "primitive" state, the more stable it will be. Wolynes' pioneering theory vividly portrays this energy as a funnel.
To test their computer models, the researchers compared them to the actual protein structures obtained by X-ray crystallography. Numerous structures are available for globularly folded proteins that float in the body and perform essential tasks of life.
However, it has been very difficult to obtain similar structures of transmembrane proteins in recent years because it is extremely difficult to extract them for imaging without damaging them. Recently, researchers have used a detergent to wash away most of the membrane on the protein of interest, Wolynes said: "It leaves a layer of fat around the protein but gives a coating that allows the entire molecule to form later Lattice. "

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