Seracare抗环瓜氨酸肽抗体(CCP)
Seracare抗环瓜氨酸肽抗体(CCP)

美国Seracare抗环瓜氨酸肽抗体(CCP)

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2022-11-29 20:40:06
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广州健仑生物科技有限公司

广州健仑生物科技有限公司

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产品简介

美国SeracareSeracare抗环瓜氨酸肽抗体(CCP) 抗原抗体 标准品 需要了解美国Seracare的产品可以,本质控品由广州健仑生物供应。

详细介绍

美国Seracare抗环瓜氨酸肽抗体(CCP) 

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料,主要代理品牌:美国Seracare、西班牙Certest、美国Fuller等等。

主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。

其中常见的有:弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。

美国Seracare抗环瓜氨酸肽抗体(CCP) 

我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

欢迎咨询

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Seracare产品介绍】

编号

英文名称

中文名称

JL-FA-01

Amebiasis (AME)

阿米巴病

JL-FA-02

Allergens, Rast scores

过敏原,放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质

JL-FA-03

Allergens, Rast scores negative

过敏原,放射性过敏原吸收实验阴性

JL-FA-04

Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis

抗环瓜氨酸肽抗体

JL-FA-05

ASCA Saccharomyces Cerevi

人抗酿酒酵母抗体(ASCA)

JL-FA-06

Aspergillis

麴菌病

JL-FA-07

Beta 2 Glycoprotein

β2糖蛋白

JL-FA-08

Beta 2 Glycoprotein  IgM

β2糖蛋白 IGM

JL-FA-09

Bordela Pertussis

百日咳杆菌

JL-FA-10

Bordela Pertussis IgM

百日咳杆菌 IGM

JL-FA-11

C-ANCA

C-抗中性粒细胞胞浆抗体(ANCA)

JL-FA-12

Cardiolipin

心肌磷脂

JL-FA-13

Cardiolipin IgA

心肌磷脂 IGA

JL-FA-14

Cardiolipin IgG

心肌磷脂 IGG

JL-FA-15

Cardiolipin IgM

心肌磷脂 IGM

JL-FA-16

Cerebral Spinal Fluid

脑脊髓液

JL-FA-17

Chagas

恰加斯病/南美锥虫

JL-FA-18

Chlamydia

衣原体

JL-FA-19

Chlamydia IgA

衣原体IGA

JL-FA-20

Chlamydia IgG

衣原体IGG

JL-FA-21

Chlamydia IgM

衣原体IGM

JL-FA-22

Chlamydia Neg

衣原体阴性

JL-FA-23

Clotting Factor C3

凝固因子C3

JL-FA-24

Clotting Factor C4

凝固因子C4

JL-FA-25

Coccidiodes

球孢菌

JL-FA-26

Cytomegalovirus (CMV) Neg

巨细胞病毒抗体阴性

JL-FA-27

CMV IgG

巨细胞病毒 IGG阳性

JL-FA-28

CMV IgM VCA

巨细胞病毒 IGM 阳性

JL-FA-29

C-Reactive Protein (CRP)

C-反应蛋白质

JL-FA-30

Dengue Fever

登革热

JL-FA-31

Dengue Fever IgM

登革热 IGM

JL-FA-32

DS (Double Stranded) DNA

双链脱氧核糖核酸

JL-FA-33

EBNA (Epstein-Barr nuclear antigen) IgG

EB病毒核抗原 IGG

JL-FA-34

EBNA (Epstein-Barr nuclear antigen) IgM

EB病毒核抗原 IGM

JL-FA-35

Epstein Barr Virus (EBV) Negative Plasma

EB病毒阴性血浆

JL-FA-36

Epstein Barr Virus (EBV) EA IgM

EB病毒早期抗原 IGM

JL-FA-37

Epstein Barr Virus (EBV) VCA IgM

EB病毒壳蛋白  IGM

JL-FA-38

Epstein Barr Virus (EBV) EA IgG

EB病毒早期抗原 IGG

JL-FA-39

EMA (Endomysial Antibodies)

肌内膜

JL-FA-40

Gliadin

麸蛋白,麦醇溶蛋白,麦胶蛋白

JL-FA-41

Gliadin IgG

麦醇溶蛋白  IGG

JL-FA-42

Gliadin IgA

麦醇溶蛋白 IGA

JL-FA-43

Glomerular Basement Membrane (GBMA)

肾小球基底膜病

JL-FA-44

Helicobacter pylori IgA

幽门螺旋杆菌IGA

JL-FA-45

Helicobacter pylori IgG

幽门螺旋杆菌IGG

JL-FA-46

Helicobacter pylori IgM

幽门螺旋杆菌IGM

JL-FA-47

Helicobacter pylori Negative

幽门螺旋杆菌阴性

JL-FA-48

Helicobacter pylori Positive Plasma

幽门螺旋杆菌阴性血浆

JL-FA-49

Hepatitis A Virus (HAV) Pos. Plasma

甲型肝炎病毒阳性血浆

JL-FA-50

Hepatitis A Virus (HAV) IgM

甲型肝炎病毒IGM

JL-FA-51

Hepatitis B Core (HBc) IgG

乙型肝炎病毒核心 IGG

JL-FA-52

Hepatitis B Core (HBc) IgM

乙型肝炎病毒核心 IGM

JL-FA-53

Anti Hbe (Antibody to HBV antigen)

乙肝抗体

JL-FA-54

Hepatitis Delta Virus

丁型肝炎病毒

JL-FA-55

HBeAg (HBV e antigen)

乙肝 E抗原

JL-FA-56

anti-HBs (HBV surface antibody)

乙肝表面抗体

JL-FA-57

Hepatitis B (HBsAg) "Chronic"

乙型肝炎(乙肝表面抗原)“慢性病

JL-FA-58

HBsAg (HBV surface antigen) Serum

乙肝表面抗原血清

JL-FA-59

HBsAg (AD)

乙肝表面抗原(AD)

JL-FA-60

HBsAg (AY)

乙肝表面抗原(AY)

JL-FA-61

HBV Positive Plasma

乙肝阳性血浆

JL-FA-62

HBV DNA Plasma

乙肝DNA血浆

JL-FA-63

HBV DNA Serum

乙肝DNA血清

JL-FA-64

HBV DNA type A

 A型 乙肝DNA

JL-FA-65

HBV DNA type B

 B型 乙肝DNA

JL-FA-66

HBV DNA type C

 C型 乙肝DNA

JL-FA-67

HBV DNA type D

 D型 乙肝DNA

JL-FA-68

HBV DNA type E

 E型 乙肝DNA

JL-FA-69

HBV DNA type F

 F型 乙肝DNA

JL-FA-70

HBV Antibody HCV Antibody Plasma CO-INFECTED

乙肝和丙肝联合感染血浆

JL-FA-71

HCV (Hepatitis C Virus) Antibody

丙型肝炎抗体

JL-FA-72

HCV Core Antigen Positive

丙肝核心抗原 阳性

JL-FA-73

HCV RNA PLASMA Genotype 1

基因1型丙肝RNA 血浆

JL-FA-74

HCV RNA PLASMA Genotype 2

基因2型丙肝RNA 血浆

JL-FA-75

HCV RNA PLASMA Genotype 3

基因3型丙肝RNA 血浆

JL-FA-76

HCV RNA PLASMA Genotype 4

基因4型丙肝RNA 血浆

JL-FA-77

HCV RNA PLASMA Genotype 5

基因5型丙肝RNA 血浆

JL-FA-78

HCV RNA PLASMA Genotype 6

基因6型丙肝RNA 血浆

JL-FA-79

HCV Riba single band

丙肝免疫印迹单波段

JL-FA-80

HCV RIBA Pos. (multiple bands)

丙肝免疫印迹阳性多波段

JL-FA-81

HCV Negative

丙肝阴性

JL-FA-82

HCV RNA Pos (quantitative)

丙肝RNA阳性(定量)

JL-FA-83

Hepatitis E

戊型肝炎

JL-FA-84

Herpes Simplex Virus (HSV)1/2 Positive Plasma

单纯性疱疹病毒1/2阳性血浆

JL-FA-85

Herpes Simplex Virus (HSV) 1 Negative Plasma

单纯性疱疹病毒1 阴性血浆

JL-FA-86

Herpes Simplex Virus (HSV) 1 IgG

单纯性疱疹病毒1 IGG

JL-FA-87

Herpes Simplex Virus (HSV 1) IgM

单纯性疱疹病毒1 IGM

JL-FA-88

Herpes Simplex Virus (HSV) 2 IgG

单纯性疱疹病毒2 IGG

JL-FA-89

Herpes Simplex Virus (HSV) 2 IgM

单纯性疱疹病毒2 IGG

JL-FA-90

Histone

组蛋白

JL-FA-91

Human Anti Mouse Ab (HAMA)

人抗鼠抗体

JL-FA-92

Human immunodeficiency virus (HIV) 1 Neg

HIV  I 阴性

JL-FA-93

anti Human immunodeficiency virus (HIV) 1 Plasma

抗HIV  I 血浆

JL-FA-94

anti Human immunodeficiency virus (HIV) 1 Serum

抗HIV  I 血清

JL-FA-95

anti Human immunodeficiency virus (HIV) 2 Western Blot Tested

抗HIV  2 免疫印迹

JL-FA-96

anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)

抗HIV 1/2 2  HIV阳性

JL-FA-97

Human immunodeficiency virus (HIV) Ag

HIV抗原

JL-FA-98

HIV RNA (quantitative) Plasma

HIV RNA 定量血浆

JL-FA-99

HIV RNA (quantitative) Serum

HIV RNA 定量血清

JL-FA-100

HIV1 Subtype A

HIV1  亚型A

JL-FA-101

HIV1 Subtype B

HIV1  亚型B

JL-FA-102

HIV1 Subtype C

HIV1  亚型C

JL-FA-103

HIV1 Subtype D

HIV1  亚型D

JL-FA-104

HIV1 Subtype E

HIV1  亚型E

JL-FA-105

HIV1 Subtype F

HIV1  亚型F

JL-FA-106

HIV1 Subtype G

HIV1  亚型G

JL-FA-107

HIV1 Subtype H

HIV1  亚型H

JL-FA-108

HIV1 Subtype J

HIV1  亚型J

JL-FA-109

HIV1 Subtype K

HIV1  亚型K

JL-FA-110

HIV1 Group O

HIV1  亚型O

JL-FA-111

Human immunodeficiency virus (HIV) 2 Antibody Plasma

HIV 2 抗体血浆

JL-FA-112

Human immunodeficiency virus (HIV) 2 Antibody Serum

HIV 2 抗体血清

JL-FA-113

HPV (Human Papiloma Virus) Negative

人乳状瘤病毒HPV阴性

JL-FA-114

HPV (Human Papiloma Virus) Positive

人乳状瘤病毒HPV阳性

JL-FA-115

Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED

HIV 抗体  HCV

JL-FA-116

Human T-cell Lymphotropic Virus (HTLV) I/II

人嗜T淋巴细胞病毒(HTLV) I/II

JL-FA-117

Human T-cell Lymphotropic Virus (HTLV) I

人嗜T淋巴细胞病毒(HTLV) I

JL-FA-118

Human T-cell Lymphotropic Virus (HTLV) II

人嗜T淋巴细胞病毒(HTLV) II

JL-FA-119

Jo-1

多发性肌炎抗原JO-1

JL-FA-120

IgE < 5,000 Ku/L

IgE < 5,000 Ku/L

JL-FA-121

Legionella

军团杆菌属

JL-FA-122

Leptospira

军团杆菌属

JL-FA-123

Lyme Disease

莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生

JL-FA-124

Lyme IgG

莱姆(氏)病 IGG

JL-FA-125

Lyme IgM

莱姆(氏)病 IGM

JL-FA-126

Lyme Disease Neg

莱姆(氏)病 阴性

JL-FA-127

Malaria

疟疾

JL-FA-128

Mononucleosis (infectious)

单核细胞增多症(有传染性的)

JL-FA-129

Mononucleosis Negative

单核细胞增多症阴性

JL-FA-130

Measles Negative

麻疹 阴性

JL-FA-131

Measles IgG

麻疹 IGG

JL-FA-132

Measles IgM

麻疹  IGM

JL-FA-133

Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)

微粒体抗甲状腺过氧化物酶抗体

JL-FA-134

Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma

微粒体抗甲状腺过氧化物酶抗体

JL-FA-135

Anti-mitochondrial antibody (AMA)

抗线粒体抗体

JL-FA-136

Multiple Sclerosis

多发性硬化症

JL-FA-137

Mumps IgG

流行性腮腺炎 IGG

JL-FA-138

Mumps Ab IgM

流行性腮腺炎抗体 IGM

JL-FA-139

Mumps Antibody Negative Plasma

流行性腮腺炎抗体阴性血浆

JL-FA-140

Mumps Antibody Negative Serum

流行性腮腺炎抗体阴性血清

JL-FA-141

Myeloma Plasma

骨髓瘤血浆

JL-FA-142

Myeloma IgA

骨髓瘤IGA

JL-FA-143

Myeloma IgE

骨髓瘤IGE

JL-FA-144

Myeloma IgG

骨髓瘤IGG

JL-FA-145

Myeloma IgM

骨髓瘤IGM

JL-FA-146

Mycoplasma

支原体

JL-FA-147

Mycoplasma Negative

支原体阴性

JL-FA-148

Mycoplasma IgG

支原体IGG

JL-FA-149

Mycoplasma IgM

支原体IGM

JL-FA-150

Mycoplasma PCR

支原体PCR

JL-FA-151

Normal Human Plasma

正常人血浆

JL-FA-152

Normal Human Serum

正常人血清

JL-FA-153

Nuclear Antibody Centromere

核抗体着丝粒

JL-FA-154

Nuclear Antibody, Speckled ANA

核抗体,斑点抗核抗体

JL-FA-155

Nuclear Antibody, Nucleolar ANA

核抗体,核仁抗核抗体

JL-FA-156

Nuclear Antibody, Homogeneous ANA

核抗体,同质抗核抗体

JL-FA-157

Nuclear Antiobody, Speckled. (ANA) Negative

核抗体,斑点。抗核抗体阴性

JL-FA-158

P-ANCA (associated neutrophil cytoplasmic antibodies)

相关的嗜中性粒细胞胞浆抗体

JL-FA-159

Parietal Cell Antibody (PCA)

胃)壁细胞抗体

JL-FA-160

Parvo positive plasma

细小病毒阳性血浆

JL-FA-161

Parvo IgM

细小病毒 IGM

JL-FA-162

Parvo IgG

细小病毒 IGG

JL-FA-163

Parvo Negative Plasma

细小病毒阴性血浆

JL-FA-164

Parvo DNA positive

细小病毒 DNA 阳性

JL-FA-165

Phospholipid Positive Plasma

磷脂阳性血浆

JL-FA-166

Prothrombin

凝血酶原,凝血因子

JL-FA-167

Rheumatoid Factor (RF) <1000 IU/mL

类风湿因子<1000 IU/mL

JL-FA-168

Rheumatoid Factor (RF) 1001-2000 IU/mL

类风湿因子1001-2000 IU/mL

JL-FA-169

Rheumatoid Factor (RF) 2001-4000 IU/mL

类风湿因子 2001-4000 IU/mL

JL-FA-170

Rheumatoid Factor (RF) 4001-5000 IU/mL

类风湿因子 4001-5000 IU/mL

JL-FA-171

Rheumatoid Factor (RF) >5000 IU/mL

类风湿因子>5000 IU/mL

JL-FA-172

Ribonucleoprotein (RNP) Positive

核糖核蛋白阳性

JL-FA-173

Rubella Chimeric

风疹

JL-FA-174

Rubella Negative

风疹阴性

JL-FA-175

Rubella IgG

风疹IGG

JL-FA-176

Rubella IgM

风疹IGM

JL-FA-177

Rubeola Negative Plasma

风疹阴性血浆

JL-FA-178

Rubeola IgG

风疹IGG

JL-FA-179

Scleroderma (Scl-70) Pos

胶原沉着病,硬皮病,硬皮症 阳性

JL-FA-180

Scleroderma (Scl-70) Negative

硬皮病阴性

JL-FA-181

Sickle Cell Fresh Whole Blood

镰刀形红细胞新鲜全血

JL-FA-182

Smith (SM)

抗Smith抗体阳性血清(SLE的特征性抗体)

JL-FA-183

SMITH RNP

抗RNP抗体阳性血清(SLE的特征性抗体)

JL-FA-184

Smooth Muscle (ASMA)

抗平滑肌抗体阳性血清

JL-FA-185

Sjogren syndrome antigen A (SSA) Positive

舍格伦综合征或干燥综合征抗原A 阳性

JL-FA-186

Sjogren syndrome antigen B (SSB) Positive

舍格伦综合征抗原B 阳性

JL-FA-187

Sjogren syndrome antigen B (SSB) Negative

舍格伦综合征抗原B阴性

JL-FA-188

Streptolysin O Ab (ASO)

链球菌溶血素O抗体

JL-FA-189

Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma

梅毒(梅毒-快速血浆反应)阳性血浆

JL-FA-190

Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma

梅毒(梅毒-快速血浆反应)阴性血浆

JL-FA-191

Syphilis/ATA/T. pallidum IgG

梅毒ATA/T,苍白球IGG

JL-FA-192

Syphilis/ATA/T. pallidum IgM

梅毒ATA/T,苍白球IGM

JL-FA-193

Systemic Lupus Erythematosus (SLE) Positive

全身性红斑狼疮阳性

JL-FA-194

Systemic Lupus Erythematosus (SLE) Negative

全身性红斑狼疮阴性

JL-FA-195

TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)

甲状腺球蛋白/甲状腺过氧化物酶阳性

JL-FA-196

TG/TPO Negative

甲状腺球蛋白/甲状腺过氧化物酶阴性

JL-FA-197

TTG (Tissue Transglutaminase)

组织转谷氨酰胺酶

JL-FA-198

TTG (Tissue Transglutaminase) IgA

组织转谷氨酰胺酶 IGA

JL-FA-199

ToRCH (Toxo, Rubella, CMV, HSV) Positive

优生优育(弓形虫,风疹,巨细胞,单胞)阳性

JL-FA-200

ToRCH (Toxo, Rubella, CMV, HSV) Negative

优生优育(弓形虫,风疹,巨细胞,单胞)阴性

JL-FA-201

Toxoplasmosis (Toxo)

弓形虫病

JL-FA-202

Toxoplasmosis (Toxo) IgG

弓形虫病IGG

JL-FA-203

Toxoplasmosis (Toxo) IgM

弓形虫病IGM

JL-FA-204

Thyroglobulin (TG) Positive Plasma

甲状腺球蛋白阳性血浆

JL-FA-205

Thyroglobulin (TG) Negative

甲状腺球蛋白阴性

JL-FA-206

Varicella-Zoster Virus (VZV) Negative

水痘-带状疱疹病毒阴性

JL-FA-207

Varicella-Zoster Virus (VZV) IgG

水痘-带状疱疹病毒IGG

JL-FA-208

Varicella-Zoster Virus (VZV) IgM

水痘-带状疱疹病毒IGM

JL-FA-209

West Nile Virus (WNV)

西尼罗河脑炎病毒

JL-FA-210

West Nile Virus (WNV) IgM

西尼罗河脑炎病毒IGM

美国Seracare抗环瓜氨酸肽抗体(CCP) 

这种循序渐进的步骤是古真核细胞发育为更大、更复杂的细胞的重要的一部分。
“这通常被认为是,细菌细胞不同于我们细胞的一个基本途径,” 沃德说。“不过,Gemmata obscuriglobus(他们所研究的细菌)的细胞具有复杂的内膜,使它们表面看起来像是真核细胞。”
Gottshall想知道,转录和翻译是否可能发生在细胞的不同地方,就像在真核生物细胞中。
“我们提出这个问题,是因为我们不能*理解,复杂的真核细胞从一个更简单的祖先进化而来的途径,并且我们认为,研究Gemmata的这个问题可能揭示这个问题的一些谜团,” Gottshall说。
人们普遍认为,动物和植物细胞的两个主要的有膜细胞器——线粒体,细胞的发电厂,以及能够发生光合作用的叶绿体——当古细菌感染并居住在古老的原真核细胞中时形成的。
一些人估计这些迁入日期约为18亿年前。细菌微生物化石zui早出现在大约35十亿年前。
沃德和她的研究小组发现大多数的G. obscuriglobus翻译和转录发生在不同的地方,和真核细胞一样。
“虽然这不是*次报道细菌,但这是*报道这样一个复杂的细菌细胞,” 沃德说。“虽然我们不知道,Gemmata是否存在一个,,导致出现与真核细胞相同的方式。它向我们展示了,它有可能成为组织化的一个方式。”
肺癌,也会影响非吸烟者,是世界上癌症死亡的主要原因。根据美国国家癌症研究所统计,美国在肺癌治疗上的花费超过120亿美元。然而,肺癌的存活率不容乐观,由于疾病极易转移到整个身体,有80%的患者在诊断后5年之内死亡。
为了获得转移性,癌细胞会覆盖一般保持细胞根植在它们各自位置的细胞器。癌症可以迂回地打开和关闭细胞膜上突起的分子锚(称为附着斑复合物),为迁移准备细胞。这使得癌细胞开始经过血流遍历体内,在新的器官驻留下来。
除了不同的癌症能控制这些锚之外,大约五分之一的肺癌病例缺失一个抗癌基因,称为LKB1(又名STK11)。缺失LKB1的癌症通常是侵袭性的,可在体内迅速蔓延。然而,没有知道LKB1和粘附斑之间是如何关联的。
现在,索尔克研究小组发现了这个关联,并发现了一个新的治疗靶点:一个鲜为人知的基因,称为DIXDC1。研究人员发现,DIXDC1接受来自LKB1的指令,转到粘着斑,并改变它们的数量和大小。
当DIXDC1被“打开”,半打左右的粘着斑变大并具有粘性,将细胞锚定在它们的位置。当DIXDC1被阻断或灭活时,粘着斑变小和量大,导致数百只小“手”向前拉动细胞,以响应细胞外的线索。转移的倾向增加,有助于癌细胞从肺部逃跑,可让肿瘤细胞存活下来,经过血液并停留在体内各处的器官。

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This step-by-step step is an important part of developing eukaryotic cells into larger, more complex cells.
"This is generally considered to be a fundamental way that bacterial cells differ from our cells," Ward said. "However, the cells of Gemmata obscuriglobus (the bacteria they studied) have complex intima, making their surfaces look like eukaryotes."
Gottshall wondered if transcription and translation might occur in different parts of the cell, just like in eukaryotic cells.
"We ask this question because we can not fully understand the complex evolved pathways of eukaryotic cells from a simpler ancestor and we think the study of Gemmata may shed some light on this issue," Gottshall said .
It is generally accepted that the two major membranous organelles of animals and plant cells - mitochondria, cellular power plants, and chloroplasts capable of photosynthesis - form when archaebacteria are infected and reside in ancient eukaryotic cells of.
Some estimate that these move-in dates are about 1.8 billion years ago. Bacterial microbial fossils first appeared about 35 billion years ago.
Ward and her team found that most of the G. obscuriglobus translation and transcription occur in different places, just like eukaryotes.
"Although this is not the first report of bacteria, it is the first time that such a complex bacterial cell has been reported," Ward said. "Although we do not know if Gemmata has one, resulting in the same appearance as eukaryotes, it shows us that it is likely to be a way of organizing."
Lung cancer, also affecting non-smokers, is the leading cause of cancer deaths in the world. According to the National Cancer Institute, the United States spends more than 12 billion U.S. dollars on lung cancer treatment. However, the survival rate of lung cancer is not optimistic, as the disease easily transferred to the entire body, 80% of patients died within 5 years after diagnosis.
In order to obtain metastaticity, cancer cells will cover organelles that generally keep the cells rooted in their respective locations. Cancers roundaboutly open and close protruding molecular anchors (called attachment plaque complexes) on the cell membrane, preparing cells for migration. This allows cancer cells to start traversing the bloodstream and residing in new organs.
In addition to the fact that different cancers can control these anchors, about one in five lung cancers lack an anti-cancer gene, called LKB1 (aka STK11). Cancers that lack LKB1 are usually aggressive and spread rapidly in the body. However, it is not known how LKB1 and adhesive spots are related.
Now, the Sork study found the link and found a new therapeutic target: a little-known gene called DIXDC1. The researchers found that DIXDC1 received instructions from LKB1, turned to sticky patches, and changed their number and size.
When DIXDC1 is "on", half a dozen sticky patches become large and sticky, anchoring the cells in their place. When DIXDC1 is blocked or inactivated, the sticky patches become small and large, causing hundreds of small "hands" to pull the cells forward in response to extracellular cues. The increased tendency to metastasize helps the cancer cells escape from the lungs, allowing the tumor cells to survive, pass through the blood and remain in the organs throughout the body.

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