美国Seracare-过敏原质控品Allergens Rast scores-,质控品广州健仑生物科技有限公司手机版

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美国Seracare过敏原质控品Allergens Rast scores

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料，主要代理品牌：美国Seracare、西班牙Certest、美国Fuller等等。

主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。

其中常见的有：弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。

美国Seracare过敏原质控品Allergens Rast scores

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【Seracare产品介绍】

编号	英文名称	中文名称
JL-FA-01	Amebiasis (AME)	阿米巴病
JL-FA-02	Allergens, Rast scores	过敏原，放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质
JL-FA-03	Allergens, Rast scores negative	过敏原，放射性过敏原吸收实验阴性
JL-FA-04	Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis	抗环瓜氨酸肽抗体
JL-FA-05	ASCA Saccharomyces Cerevi	人抗酿酒酵母抗体（ASCA）
JL-FA-06	Aspergillis	麴菌病
JL-FA-07	Beta 2 Glycoprotein	β2糖蛋白
JL-FA-08	Beta 2 Glycoprotein IgM	β2糖蛋白 IGM
JL-FA-09	Bordela Pertussis	百日咳杆菌
JL-FA-10	Bordela Pertussis IgM	百日咳杆菌 IGM
JL-FA-11	C-ANCA	C-抗中性粒细胞胞浆抗体（ANCA)
JL-FA-12	Cardiolipin	心肌磷脂
JL-FA-13	Cardiolipin IgA	心肌磷脂 IGA
JL-FA-14	Cardiolipin IgG	心肌磷脂 IGG
JL-FA-15	Cardiolipin IgM	心肌磷脂 IGM
JL-FA-16	Cerebral Spinal Fluid	脑脊髓液
JL-FA-17	Chagas	恰加斯病/南美锥虫
JL-FA-18	Chlamydia	衣原体
JL-FA-19	Chlamydia IgA	衣原体IGA
JL-FA-20	Chlamydia IgG	衣原体IGG
JL-FA-21	Chlamydia IgM	衣原体IGM
JL-FA-22	Chlamydia Neg	衣原体阴性
JL-FA-23	Clotting Factor C3	凝固因子C3
JL-FA-24	Clotting Factor C4	凝固因子C4
JL-FA-25	Coccidiodes	球孢菌
JL-FA-26	Cytomegalovirus (CMV) Neg	巨细胞病毒抗体阴性
JL-FA-27	CMV IgG	巨细胞病毒 IGG阳性
JL-FA-28	CMV IgM VCA	巨细胞病毒 IGM 阳性
JL-FA-29	C-Reactive Protein (CRP)	C-反应蛋白质
JL-FA-30	Dengue Fever	登革热
JL-FA-31	Dengue Fever IgM	登革热 IGM
JL-FA-32	DS (Double Stranded) DNA	双链脱氧核糖核酸
JL-FA-33	EBNA (Epstein-Barr nuclear antigen) IgG	EB病毒核抗原 IGG
JL-FA-34	EBNA (Epstein-Barr nuclear antigen) IgM	EB病毒核抗原 IGM
JL-FA-35	Epstein Barr Virus (EBV) Negative Plasma	EB病毒阴性血浆
JL-FA-36	Epstein Barr Virus (EBV) EA IgM	EB病毒早期抗原 IGM
JL-FA-37	Epstein Barr Virus (EBV) VCA IgM	EB病毒壳蛋白 IGM
JL-FA-38	Epstein Barr Virus (EBV) EA IgG	EB病毒早期抗原 IGG
JL-FA-39	EMA (Endomysial Antibodies)	肌内膜
JL-FA-40	Gliadin	麸蛋白,麦醇溶蛋白,麦胶蛋白
JL-FA-41	Gliadin IgG	麦醇溶蛋白 IGG
JL-FA-42	Gliadin IgA	麦醇溶蛋白 IGA
JL-FA-43	Glomerular Basement Membrane (GBMA)	肾小球基底膜病
JL-FA-44	Helicobacter pylori IgA	幽门螺旋杆菌IGA
JL-FA-45	Helicobacter pylori IgG	幽门螺旋杆菌IGG
JL-FA-46	Helicobacter pylori IgM	幽门螺旋杆菌IGM
JL-FA-47	Helicobacter pylori Negative	幽门螺旋杆菌阴性
JL-FA-48	Helicobacter pylori Positive Plasma	幽门螺旋杆菌阴性血浆
JL-FA-49	Hepatitis A Virus (HAV) Pos. Plasma	甲型肝炎病毒阳性血浆
JL-FA-50	Hepatitis A Virus (HAV) IgM	甲型肝炎病毒IGM
JL-FA-51	Hepatitis B Core (HBc) IgG	乙型肝炎病毒核心 IGG
JL-FA-52	Hepatitis B Core (HBc) IgM	乙型肝炎病毒核心 IGM
JL-FA-53	Anti Hbe (Antibody to HBV antigen)	乙肝抗体
JL-FA-54	Hepatitis Delta Virus	丁型肝炎病毒
JL-FA-55	HBeAg (HBV e antigen)	乙肝 E抗原
JL-FA-56	anti-HBs (HBV surface antibody)	乙肝表面抗体
JL-FA-57	Hepatitis B (HBsAg) "Chronic"	乙型肝炎（乙肝表面抗原）“慢性病
JL-FA-58	HBsAg (HBV surface antigen) Serum	乙肝表面抗原血清
JL-FA-59	HBsAg (AD)	乙肝表面抗原（AD）
JL-FA-60	HBsAg (AY)	乙肝表面抗原（AY）
JL-FA-61	HBV Positive Plasma	乙肝阳性血浆
JL-FA-62	HBV DNA Plasma	乙肝DNA血浆
JL-FA-63	HBV DNA Serum	乙肝DNA血清
JL-FA-64	HBV DNA type A	A型乙肝DNA
JL-FA-65	HBV DNA type B	B型乙肝DNA
JL-FA-66	HBV DNA type C	C型乙肝DNA
JL-FA-67	HBV DNA type D	D型乙肝DNA
JL-FA-68	HBV DNA type E	E型乙肝DNA
JL-FA-69	HBV DNA type F	F型乙肝DNA
JL-FA-70	HBV Antibody HCV Antibody Plasma CO-INFECTED	乙肝和丙肝联合感染血浆
JL-FA-71	HCV (Hepatitis C Virus) Antibody	丙型肝炎抗体
JL-FA-72	HCV Core Antigen Positive	丙肝核心抗原阳性
JL-FA-73	HCV RNA PLASMA Genotype 1	基因1型丙肝RNA 血浆
JL-FA-74	HCV RNA PLASMA Genotype 2	基因2型丙肝RNA 血浆
JL-FA-75	HCV RNA PLASMA Genotype 3	基因3型丙肝RNA 血浆
JL-FA-76	HCV RNA PLASMA Genotype 4	基因4型丙肝RNA 血浆
JL-FA-77	HCV RNA PLASMA Genotype 5	基因5型丙肝RNA 血浆
JL-FA-78	HCV RNA PLASMA Genotype 6	基因6型丙肝RNA 血浆
JL-FA-79	HCV Riba single band	丙肝免疫印迹单波段
JL-FA-80	HCV RIBA Pos. (multiple bands)	丙肝免疫印迹阳性多波段
JL-FA-81	HCV Negative	丙肝阴性
JL-FA-82	HCV RNA Pos (quantitative)	丙肝RNA阳性（定量）
JL-FA-83	Hepatitis E	戊型肝炎
JL-FA-84	Herpes Simplex Virus (HSV)1/2 Positive Plasma	单纯性疱疹病毒1/2阳性血浆
JL-FA-85	Herpes Simplex Virus (HSV) 1 Negative Plasma	单纯性疱疹病毒1 阴性血浆
JL-FA-86	Herpes Simplex Virus (HSV) 1 IgG	单纯性疱疹病毒1 IGG
JL-FA-87	Herpes Simplex Virus (HSV 1) IgM	单纯性疱疹病毒1 IGM
JL-FA-88	Herpes Simplex Virus (HSV) 2 IgG	单纯性疱疹病毒2 IGG
JL-FA-89	Herpes Simplex Virus (HSV) 2 IgM	单纯性疱疹病毒2 IGG
JL-FA-90	Histone	组蛋白
JL-FA-91	Human Anti Mouse Ab (HAMA)	人抗鼠抗体
JL-FA-92	Human immunodeficiency virus (HIV) 1 Neg	HIV I 阴性
JL-FA-93	anti Human immunodeficiency virus (HIV) 1 Plasma	抗HIV I 血浆
JL-FA-94	anti Human immunodeficiency virus (HIV) 1 Serum	抗HIV I 血清
JL-FA-95	anti Human immunodeficiency virus (HIV) 2 Western Blot Tested	抗HIV 2 免疫印迹
JL-FA-96	anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)	抗HIV 1/2 2 HIV阳性
JL-FA-97	Human immunodeficiency virus (HIV) Ag	HIV抗原
JL-FA-98	HIV RNA (quantitative) Plasma	HIV RNA 定量血浆
JL-FA-99	HIV RNA (quantitative) Serum	HIV RNA 定量血清
JL-FA-100	HIV1 Subtype A	HIV1 亚型A
JL-FA-101	HIV1 Subtype B	HIV1 亚型B
JL-FA-102	HIV1 Subtype C	HIV1 亚型C
JL-FA-103	HIV1 Subtype D	HIV1 亚型D
JL-FA-104	HIV1 Subtype E	HIV1 亚型E
JL-FA-105	HIV1 Subtype F	HIV1 亚型F
JL-FA-106	HIV1 Subtype G	HIV1 亚型G
JL-FA-107	HIV1 Subtype H	HIV1 亚型H
JL-FA-108	HIV1 Subtype J	HIV1 亚型J
JL-FA-109	HIV1 Subtype K	HIV1 亚型K
JL-FA-110	HIV1 Group O	HIV1 亚型O
JL-FA-111	Human immunodeficiency virus (HIV) 2 Antibody Plasma	HIV 2 抗体血浆
JL-FA-112	Human immunodeficiency virus (HIV) 2 Antibody Serum	HIV 2 抗体血清
JL-FA-113	HPV (Human Papiloma Virus) Negative	人乳状瘤病毒HPV阴性
JL-FA-114	HPV (Human Papiloma Virus) Positive	人乳状瘤病毒HPV阳性
JL-FA-115	Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED	HIV 抗体 HCV
JL-FA-116	Human T-cell Lymphotropic Virus (HTLV) I/II	人嗜T淋巴细胞病毒(HTLV) I/II
JL-FA-117	Human T-cell Lymphotropic Virus (HTLV) I	人嗜T淋巴细胞病毒(HTLV) I
JL-FA-118	Human T-cell Lymphotropic Virus (HTLV) II	人嗜T淋巴细胞病毒(HTLV) II
JL-FA-119	Jo-1	多发性肌炎抗原JO-1
JL-FA-120	IgE < 5,000 Ku/L	IgE < 5,000 Ku/L
JL-FA-121	Legionella	军团杆菌属
JL-FA-122	Leptospira	军团杆菌属
JL-FA-123	Lyme Disease	莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生
JL-FA-124	Lyme IgG	莱姆(氏)病 IGG
JL-FA-125	Lyme IgM	莱姆(氏)病 IGM
JL-FA-126	Lyme Disease Neg	莱姆(氏)病阴性
JL-FA-127	Malaria	疟疾
JL-FA-128	Mononucleosis (infectious)	单核细胞增多症（有传染性的）
JL-FA-129	Mononucleosis Negative	单核细胞增多症阴性
JL-FA-130	Measles Negative	麻疹阴性
JL-FA-131	Measles IgG	麻疹 IGG
JL-FA-132	Measles IgM	麻疹 IGM
JL-FA-133	Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)	微粒体抗甲状腺过氧化物酶抗体
JL-FA-134	Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma	微粒体抗甲状腺过氧化物酶抗体
JL-FA-135	Anti-mitochondrial antibody (AMA)	抗线粒体抗体
JL-FA-136	Multiple Sclerosis	多发性硬化症
JL-FA-137	Mumps IgG	流行性腮腺炎 IGG
JL-FA-138	Mumps Ab IgM	流行性腮腺炎抗体 IGM
JL-FA-139	Mumps Antibody Negative Plasma	流行性腮腺炎抗体阴性血浆
JL-FA-140	Mumps Antibody Negative Serum	流行性腮腺炎抗体阴性血清
JL-FA-141	Myeloma Plasma	骨髓瘤血浆
JL-FA-142	Myeloma IgA	骨髓瘤IGA
JL-FA-143	Myeloma IgE	骨髓瘤IGE
JL-FA-144	Myeloma IgG	骨髓瘤IGG
JL-FA-145	Myeloma IgM	骨髓瘤IGM
JL-FA-146	Mycoplasma	支原体
JL-FA-147	Mycoplasma Negative	支原体阴性
JL-FA-148	Mycoplasma IgG	支原体IGG
JL-FA-149	Mycoplasma IgM	支原体IGM
JL-FA-150	Mycoplasma PCR	支原体PCR
JL-FA-151	Normal Human Plasma	正常人血浆
JL-FA-152	Normal Human Serum	正常人血清
JL-FA-153	Nuclear Antibody Centromere	核抗体着丝粒
JL-FA-154	Nuclear Antibody, Speckled ANA	核抗体，斑点抗核抗体
JL-FA-155	Nuclear Antibody, Nucleolar ANA	核抗体,核仁抗核抗体
JL-FA-156	Nuclear Antibody, Homogeneous ANA	核抗体，同质抗核抗体
JL-FA-157	Nuclear Antiobody, Speckled. (ANA) Negative	核抗体，斑点。抗核抗体阴性
JL-FA-158	P-ANCA (associated neutrophil cytoplasmic antibodies)	相关的嗜中性粒细胞胞浆抗体
JL-FA-159	Parietal Cell Antibody (PCA)	胃)壁细胞抗体
JL-FA-160	Parvo positive plasma	细小病毒阳性血浆
JL-FA-161	Parvo IgM	细小病毒 IGM
JL-FA-162	Parvo IgG	细小病毒 IGG
JL-FA-163	Parvo Negative Plasma	细小病毒阴性血浆
JL-FA-164	Parvo DNA positive	细小病毒 DNA 阳性
JL-FA-165	Phospholipid Positive Plasma	磷脂阳性血浆
JL-FA-166	Prothrombin	凝血酶原,凝血因子
JL-FA-167	Rheumatoid Factor (RF) <1000 IU/mL	类风湿因子<1000 IU/mL
JL-FA-168	Rheumatoid Factor (RF) 1001-2000 IU/mL	类风湿因子1001-2000 IU/mL
JL-FA-169	Rheumatoid Factor (RF) 2001-4000 IU/mL	类风湿因子 2001-4000 IU/mL
JL-FA-170	Rheumatoid Factor (RF) 4001-5000 IU/mL	类风湿因子 4001-5000 IU/mL
JL-FA-171	Rheumatoid Factor (RF) >5000 IU/mL	类风湿因子>5000 IU/mL
JL-FA-172	Ribonucleoprotein (RNP) Positive	核糖核蛋白阳性
JL-FA-173	Rubella Chimeric	风疹
JL-FA-174	Rubella Negative	风疹阴性
JL-FA-175	Rubella IgG	风疹IGG
JL-FA-176	Rubella IgM	风疹IGM
JL-FA-177	Rubeola Negative Plasma	风疹阴性血浆
JL-FA-178	Rubeola IgG	风疹IGG
JL-FA-179	Scleroderma (Scl-70) Pos	胶原沉着病,硬皮病,硬皮症阳性
JL-FA-180	Scleroderma (Scl-70) Negative	硬皮病阴性
JL-FA-181	Sickle Cell Fresh Whole Blood	镰刀形红细胞新鲜全血
JL-FA-182	Smith (SM)	抗Smith抗体阳性血清（SLE的特征性抗体）
JL-FA-183	SMITH RNP	抗RNP抗体阳性血清（SLE的特征性抗体）
JL-FA-184	Smooth Muscle (ASMA)	抗平滑肌抗体阳性血清
JL-FA-185	Sjogren syndrome antigen A (SSA) Positive	舍格伦综合征或干燥综合征抗原A 阳性
JL-FA-186	Sjogren syndrome antigen B (SSB) Positive	舍格伦综合征抗原B 阳性
JL-FA-187	Sjogren syndrome antigen B (SSB) Negative	舍格伦综合征抗原B阴性
JL-FA-188	Streptolysin O Ab (ASO)	链球菌溶血素O抗体
JL-FA-189	Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma	梅毒（梅毒-快速血浆反应）阳性血浆
JL-FA-190	Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma	梅毒（梅毒-快速血浆反应）阴性血浆
JL-FA-191	Syphilis/ATA/T. pallidum IgG	梅毒ATA/T，苍白球IGG
JL-FA-192	Syphilis/ATA/T. pallidum IgM	梅毒ATA/T，苍白球IGM
JL-FA-193	Systemic Lupus Erythematosus (SLE) Positive	全身性红斑狼疮阳性
JL-FA-194	Systemic Lupus Erythematosus (SLE) Negative	全身性红斑狼疮阴性
JL-FA-195	TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)	甲状腺球蛋白/甲状腺过氧化物酶阳性
JL-FA-196	TG/TPO Negative	甲状腺球蛋白/甲状腺过氧化物酶阴性
JL-FA-197	TTG (Tissue Transglutaminase)	组织转谷氨酰胺酶
JL-FA-198	TTG (Tissue Transglutaminase) IgA	组织转谷氨酰胺酶 IGA
JL-FA-199	ToRCH (Toxo, Rubella, CMV, HSV) Positive	优生优育（弓形虫，风疹，巨细胞，单胞）阳性
JL-FA-200	ToRCH (Toxo, Rubella, CMV, HSV) Negative	优生优育（弓形虫，风疹，巨细胞，单胞）阴性
JL-FA-201	Toxoplasmosis (Toxo)	弓形虫病
JL-FA-202	Toxoplasmosis (Toxo) IgG	弓形虫病IGG
JL-FA-203	Toxoplasmosis (Toxo) IgM	弓形虫病IGM
JL-FA-204	Thyroglobulin (TG) Positive Plasma	甲状腺球蛋白阳性血浆
JL-FA-205	Thyroglobulin (TG) Negative	甲状腺球蛋白阴性
JL-FA-206	Varicella-Zoster Virus (VZV) Negative	水痘-带状疱疹病毒阴性
JL-FA-207	Varicella-Zoster Virus (VZV) IgG	水痘-带状疱疹病毒IGG
JL-FA-208	Varicella-Zoster Virus (VZV) IgM	水痘-带状疱疹病毒IGM
JL-FA-209	West Nile Virus (WNV)	西尼罗河脑炎病毒
JL-FA-210	West Nile Virus (WNV) IgM	西尼罗河脑炎病毒IGM

美国Seracare

该研究小组发现，两种不同的B细胞谱系抗体联手，刺激备受追捧的广谱中和抗体对抗HIV。该研究组由杜克大学艾滋病毒/艾滋病疫苗免疫学，免疫原发现(CHAVI-ID)中心杜克大学人类疫苗研究所的主任巴顿·海恩斯，以及该疫苗研究中心的国家过敏和传染病研究所(NIAID)的主任John Mascola医学博士所的。
海恩斯说，这些可中和多种hiv病毒株的抗体的激活是是一个性疫苗的关键策略。高水平的这种抗体在约20%的艾滋病毒感染者中产生。
去年，该研究组在Nature杂志上*描述广谱中和抗体(bnAbs)的共同进化，以及病毒激活感染者内的这些抗体。现在，同样的研究小组报告了患者体内的免疫系统的B细胞学会中和许多种HIV病毒株的确切机制。
在这项新研究中，科学家惊讶地发现，一个辅助的中和抗体组和交叉反应中和抗体合作，产生一套强而有力的广谱中和抗体。其他辅助谱系包含与导致感染的病毒中和的抗体。
这种抗体靶向病毒的外膜区域，该区域也能够与广谱中和抗体结合。在这样做时，辅助谱系抗体选择具有较强能力的病毒刺激广谱中和抗体系。
因此，一组抗体选择一组病毒逃逸突变体“教导”广谱中和抗体系如何中和HIV变种。科学家推测，这个过程会反复发生在整个感染中，导致中和多种HIV毒株的抗体谱的产生。
“一个bnAb谱系的成熟可以通过辅助谱系来提升的这一发现，对艾滋病疫苗的发展有着重要的影响，”文章*作者、杜克大学人类疫苗研究所Feng Gao博士说。“来自于初始传播/原始病毒的免疫原的反复免疫，以及逃避变体与bnAb谱系具有更高的结合能力，都可能需要激活bnAbs。”
“下一步是要在能够产生广谱中和抗体的其他个体中进行类似的研究，并确定诱导这种抗体的其他特异性是一个普遍的机制，” 海恩斯说。“然后，zui终证明，这一发现可用于设计可诱导广谱中和抗体的免疫原。”
利用这项研究的结果，该研究模仿自然感染艾滋病毒的光谱中和抗体发展，已经设计出一种疫苗免疫原，有选择性地触发产生抗体的B细胞进行合作，产生广谱中和抗体。
随着癌症的发育，正常的血液供给慢慢不能满足其需求，因此过度生长的肿瘤组织吸收的氧气量就会比正常组织少，这种低氧环境称之为缺氧状态，缺氧状态往往和不同类型的恶性肿瘤的发生相关。
这项研究中研究人员利用结肠癌组织进行研究发现，缺氧条件可以诱发关键的肿瘤抑制基因MLH1发生沉默;与此同时研究人员也发现了一种名为LSD1的酶类，这种酶是一种赖氨酸特殊的脱甲基酶，酶类LSD1连同MLH1都可以作为逆转或者阻断沉默过程的靶点;由于LSD1是一种特殊酶类，因此科学家们可以利用小分子对其产生的靶向作用来抑制其活性。

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The team found that two different B-cell lineage antibodies work in tandem to stimulate the highly sought-after broad-spectrum neutralizing antibodies against HIV. The research team was led by Barton Haynes, director of the Duke University HIV Vaccine Immunology, Duke University Center for Human Immunization Discovery (CHAVI-ID) Center at Duke University, and the National Allergy and Infectious Diseases Led by John Mascola, MD, director of the Institute (NIAID).
Haynes said the activation of antibodies that neutralize multiple hiv strains is a key strategy for a global vaccine. High levels of this antibody are produced in about 20% of HIV-infected individuals.
Last year, the team first described in Nature the co-evolution of broad-spectrum neutralizing antibodies (bnAbs), and the virus activates these antibodies in infected individuals. The same team now reports on the exact mechanism by which B cells in the immune system in a patient learn to neutralize many types of HIV strains.
In this new study, scientists were surprised to find that a co-neutralizing antibody group works with cross-reacting neutralizing antibodies to produce a robust set of broad-spectrum neutralizing antibodies. Other accessory lineages contain antibodies that neutralize the virus that causes the infection.
This antibody targets the outer membrane region of the virus, which is also capable of binding to a broad spectrum of neutralizing antibodies. In doing so, the accessory lineage antibody selects a more competent virus to stimulate the broad-spectrum neutralizing antibody system.
Thus, a panel of antibodies selected from a group of virus escape mutants "teaches" how broad-spectrum neutralizing antigens neutralize HIV variants. Scientists speculate that this process occurs repeatedly throughout the infection, resulting in the production of antibody profiles that neutralize multiple HIV strains.
"The discovery that the maturation of a bnAb lineage can be enhanced by ancillary lineages has a significant impact on the development of an AIDS vaccine," said lead author Feng Gao, PhD, of Duke University's Human Vaccine Institute. "Repeated immunizations from immunogens that originate / originate the virus, and the ability of escape variants to bind to the bnAb lineage, may require the activation of bnAbs."
"The next step is to do similar research in other individuals that are capable of producing broad-spectrum neutralizing antibodies and to establish that other specificities that induce such antibodies are a common mechanism," Haines said. "And then it turns out that this finding can be used to design immunogens that induce broad-spectrum neutralizing antibodies."
Using the results of this study, which mimicked the development of neutralizing antibodies in naturally infected HIV, a vaccine immunogen has been designed that selectively triggers the production of antibody-producing B cells to produce broad-spectrum neutralizing antibodies.
With the development of cancer, the normal blood supply slowly can not meet their needs, so excessive growth of tumor tissue to absorb oxygen than the normal tissue less, this hypoxic environment called hypoxia, hypoxia often And different types of malignancies related to the occurrence.
In this study, researchers using colon cancer tissue research found that hypoxia can induce key tumor suppressor gene MLH1 silence; at the same time researchers also found a class called LSD1 enzymes, this enzyme is a Species of lysine-specific demethylase, enzymes LSD1 together with MLH1 can be used as a reversal or block the target of the process of silencing; because LSD1 is a special enzyme, so scientists can use small molecules on their target To act to inhibit its activity.

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