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美国Seracare大肠杆菌O91阳性对照
广州健仑生物科技有限公司
广州健仑长期供应各种生物原料,主要代理品牌:美国Seracare、西班牙Certest、美国Fuller等等。
主要产品包括各种标准品、阳性对照品、阳性质控品、单克隆抗原抗体。
其中常见的有:弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。
美国Seracare大肠杆菌O91阳性对照
我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
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【Seracare产品介绍】
货号 | 中文名称 | 英文名称 |
JL-SC001 | 鼠伤寒沙门氏菌阳性对照 | Salmonella typhimurium Positive Control |
JL-SC002 | 志贺氏菌属阳性对照 | Shigella Species Positive Control |
JL-SC003 | 弧菌属阳性对照 | Vibrio Species Positive Control |
JL-SC004 | 军团菌嗜肺军团菌阳性对照 | Legionella pneumophila Positive Control |
JL-SC005 | BacTrace®金黄色葡萄球菌阳性对照 | BacTrace® Staphylococcus aureus Positive Control |
JL-SC006 | Bactrace®化脓性链球菌阳性对照 | BacTrace® Streptococcus pyogenes Positive Control |
JL-SC007 | bactrace®无乳链球菌阳性对照 | BacTrace® Streptococcus agalactiae Positive Control |
JL-SC008 | 李斯特菌属特异性阳性对照 | Listeria, Genus-Specific Positive Control |
JL-SC009 | 弯曲菌属特异性阳性对照 | Campylobacter, Genus-Specific Positive Control |
JL-SC010 | 幽门螺旋杆菌阳性对照 | Helicobacter pylori Positive Control |
JL-SC011 | 大肠杆菌O157:H7阳性对照 | Escherichia coli O157:H7 Positive Control |
JL-SC012 | BacTrace®大肠杆菌O111:H8物种阳性对照 | BacTrace® Escherichia coli O111:H8 Species Positive Control |
JL-SC013 | BacTrace®大肠杆菌O26:H11物种阳性对照 | BacTrace® Escherichia coli O26:H11 Species Positive Control |
JL-SC014 | Bactrace®大肠杆菌O103:H8的阳性对照,热灭活 | BacTrace® E.coli O103:H8 Positive Control, Heat-Killed |
JL-SC015 | Bactrace®大肠杆菌O145:H2的阳性对照,热灭活 | BacTrace® E.coli O145:H2 Positive Control, Heat-Killed |
JL-SC016 | Bactrace®大肠杆菌O121:H19的阳性对照,热灭活 | BacTrace® E.coli O121:H19 Positive Control, Heat-Killed |
JL-SC017 | Bactrace®大肠杆菌O45:H2的阳性对照,热灭活 | BacTrace® E.coli O45:H2 Positive Control, Heat-Killed |
JL-SC018 | BacTrace®大肠杆菌O104:H12阳性对照 | BacTrace® Escherichia coli O104:H12 Positive Control |
JL-SC019 | BacTrace® | BacTrace® Escherichia coli O91 Positive Control |
JL-SC020 | 鲑肾杆菌阳性对照 | Renibacterium salmoninarum Positive Control |
美国Seracare
Müller 及其同事发现,从GBM患者血液中所取样的循环肿瘤细胞要比在这些病人中预计发现的颅外肿瘤数多得多。他们没有发现对颅脑肿瘤动手术会增加肿瘤细胞在其它地方循环的任何证据。
在一篇相关的《焦点》文章中,Lara Perryman和Janine Erler提出,对GBM患者血液做循环肿瘤细胞筛检可帮助确定哪些病人可能成为合适的器官捐赠者。他们提示,这些循环细胞还可被用作一种监测该脑肿瘤进展与治疗的新方法。
多数细胞不能分裂,除非有足够的氧气存在以支持它们的后代,但是某些癌细胞和其他细胞类型规避了这个规则。现在,美国约翰霍普金斯大学的研究人员鉴定出废除细胞警告信号的机制,使得癌细胞能够继续分裂即使在没有强大的血液供给条件下。在这个过程中,研究人员发现溶酶体——细胞的蛋白质‘重复利用中心’——帮助控制细胞分裂的决定。他们还发现了新的证据表明某些药物能够停止肿瘤的生长,具有高水平的蛋白HIF-1α。
低水平氧气促进HIF-1α的产生与活化,它以两种方式保护细胞。首先,它开启一些基因产生蛋白帮助细胞适应氧气不足。它也能停止DNA复制,防止细胞分裂并增加更多需氧细胞到一个已经很恶劣的环境中。
了解某些细胞忽略HIF-1α的警告并且继续分裂,Gregg Semenza博士及其团队寻找HIF-1α与Cdk1、Cdk2之间的关系,这一蛋白已知调节细胞分裂的决定。他们发现HIF-1α与两者可以相互作用,但是Cdk1增加HIF-1α水平,而Cdk2减低HIF-1α水平。
Semenza的团队怀疑Cdk1与Cdk2按照HIF-1α的指示行事通过细胞的微型“垃圾处理器”称为蛋白酶体标记或者不标记毁灭。但是,当研究人员限制蛋白酶体的功能后,他们发现并没有改变HIF-1α的水平。相反,结果证明是Cdk1与Cdk2通过细胞的溶酶体标记或者不标记毁灭改变了HIF-1α水平。就他们所知,这是*次发现溶酶体牵涉到细胞的分裂决定中。
值得注意的是,在某些肿瘤细胞中,Cdk2能够增加HIF-1α的水平同时也刺激其基因激活作用。有效效应是细胞连续分裂同时应付低氧水平。在培养的细胞中,药物抑制Cdk1以防止HIF-1α水平的下降,并且恢复停止细胞分裂的能力,揭示它们也许能有效治疗某些肿瘤。
美国Seracare
我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、食品安全、化妆品检测、药物滥用检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
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【公司名称】 广州健仑生物科技有限公司
【市场部】 杨永汉
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【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室
Müller and colleagues found that circulating tumor cells sampled from the blood of GBM patients were much more numerous than the extracranial tumors expected to be found in these patients. They found no evidence that cranial brain surgery would increase the circulation of tumor cells elsewhere.
In a related Focus article, Lara Perryman and Janine Erler suggest that circulating tumor cell screening of GBM patients' blood can help determine which patients may be suitable organ donors. They suggest that these circulating cells may also be used as a new method of monitoring the progress and treatment of this brain tumor.
Most cells can not divide unless certain oxygen is present to support their offspring, but some cancers and other cell types circumvent this rule. Now, researchers at Johns Hopkins University in the United States have identified a mechanism to abolish cellular warning signals so that cancer cells can continue dividing even without a strong blood supply. In the process, researchers found that lysosomes - the cellular protein 'recycle center' - helped to control cell division. They also found new evidence that certain drugs stop tumor growth and have high levels of protein HIF-1α.
Low levels of oxygen promote HIF-1α production and activation, which protects cells in two ways. First, it turns on some gene-producing proteins to help cells adapt to oxygen deficiency. It also stops DNA replication, prevents cell division and adds more aerobic cells to an already harsh environment.
Knowing some cells ignore the warning of HIF-1α and continue to divide, Dr. Gregg Semenza and his team looked for a relationship between HIF-1α and Cdk1, Cdk2, a protein known to regulate cell division. They found that HIF-1α interacted with both, but Cdk1 increased HIF-1α levels and Cdk2 decreased HIF-1α levels.
Semenza's team suspects that Cdk1 and Cdk2, acting on HIF-1α's targets, are called proteasome tags or unmarked annihilation through the cells' tiny "garbage disposers." However, when researchers limited proteasome function, they found that they did not alter HIF-1α levels. Conversely, the results demonstrate that altering HIF-1Î ± levels by lysosomal or unlabeled destruction of Cdk1 and Cdk2 by cells. To the best of their knowledge, this is the first discovery that lysosomes are involved in cell division decisions.
It is noteworthy that in some tumor cells, Cdk2 can increase the level of HIF-1α and also stimulate its gene activation. The effective effect is the continuous division of cells while dealing with hypoxia levels. In cultured cells, the drug inhibits Cdk1 to prevent a decrease in HIF-1α levels and resumes its ability to stop cell division, revealing that they may be effective in treating certain tumors.