美国Seracare热灭活大肠杆菌O103:H8阳性对照

广州健仑生物科技有限公司

广州健仑长期供应各种生物原料，主要代理品牌：美国Seracare、西班牙Certest、美国Fuller等等。

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美国Seracare热灭活大肠杆菌O103:H8阳性对照

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PARS可以同时定位DNA、RNA和蛋白，“但仍然受到抗体扩散能力的限制，”Gradinaru说。因此在使用这一技术时，使用纳米抗体等较小的标记。另外，数据处理也是PARS面临的一大挑战。
日本RIKEN和东京大学的科学家们，将组织脱色与光切荧光显微镜结合起来，成像了多种器官乃至整个生物体，得到了极为详细的内部图像。这一成果发表在本期的Cell杂志上。
理解生命的运作方式是一直系统生物学的*梦想。将组织和生物体透明化然后进行单细胞分辨率的精确成像，将成为实现这一梦想的全新途径。
研究人员在这项研究中采用了一种名为CUBIC（Clear, Unobstructed Brain Imaging Cocktails and Computational Analysis）的方法，他们之前曾用这个方法成像了整个大脑。大脑组织富含脂类比较容易透明化，但机体其他部分含有许多能够吸收光的生色团（chromophore），比如血红素heme。血红素是血红蛋白的重要组分，存在于机体的绝大多数组织，并且会阻断光线。
研究人员在针对这个问题进行研究时，意外发现CUBIC试剂中的氨基醇能够将血红素从血红蛋白中提取出来，由此显著提高器官的透明度。
他们用这个方法处理小鼠的大脑、心脏、肺、肾脏、肝脏甚至整个幼鼠和成年小鼠，得到了异常透明的小鼠。在此基础上的光切（light-sheet）荧光显微成像，获得了非常清晰的3D图像。为了测试这个方法的实用性，研究人员比较了糖尿病和非糖尿病小鼠的胰腺，发现它们的胰岛存在明显的差异，胰岛是胰腺生产胰岛素的结构。
CUBIC需要用试剂固定组织，所以不能用于活体生物。不过，CUBIC可以帮助人们深入了解器官的3D结构，以及特定基因在不同组织中的表达，文章的*作者Kazuki Tainaka说。“我们的方法能得到几乎全身透明的幼鼠和成年小鼠。通过这个技术人们能观察到组织里的细胞网络，这是生物学和医学领域的一个基本挑战。”
“CUBIC可以用于3D病理学研究、解剖学研究和整个生物体的免疫组化分析。举例来说，可以用CUBIC在细胞水平上观察胚胎的发育，或者癌症和自身免疫疾病的发展。深入理解疾病的过程，有助于我们开发新的治疗策略。在单细胞水平上的全身成像，有望实现系统生物学领域的*梦想，”这项研究的*Hiroki Ueda说。
研究团队正在进一步改进显微成像方法，以便快速成像成年小鼠的整个机体甚至人类大脑。他们希望通过这一技术，深入理解自身免疫疾病和精神疾病的机制。

美国Seracare

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、食品安全、化妆品检测、药物滥用检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

PARS can position DNA, RNA and proteins simultaneously, "but is still limited by the ability of antibodies to proliferate," said Gradinaru. Therefore, in the use of this technology, it is best to use smaller labels such as Nanobodies. In addition, data processing is also a major challenge facing PARS.
Scientists at Japan's RIKEN and the University of Tokyo combined tissue decolorization with light-cut fluorescence microscopy to image a wide range of organs and even entire organisms and obtain extremely detailed internal images. This result is published in this issue of Cell magazine.
Understanding the way life works is the ultimate dream of systems biology. Transparency of tissues and organisms followed by precise imaging of single-cell resolution will be a new way to achieve this dream.
In this study, the researchers used a method called CUBIC (Clear, Unobstructed Brain Imaging Cocktails and Computational Analysis), which they had previously used to image the entire brain. Cerebral tissue is more lipid-rich and more transparent, but the rest of the body contains many chromophores that absorb light, such as heme. Heme is an important component of hemoglobin, exists in the vast majority of the body's tissues, and will block the light.
Researchers in the study of this issue, the accidental discovery of CUBIC reagent amino alcohol can hemoglobin extracted from hemoglobin, thereby significantly improving organ transparence.
Using this method, they treated the mouse's brain, heart, lungs, kidneys, liver, and even the entire young and adult mice to obtain abnormally transparent mice. On the basis of this light-sheet fluorescence microscopy, a very sharp 3D image was obtained. To test the usefulness of this method, the researchers compared the pancreata in diabetic and non-diabetic mice and found a clear difference in their islets, the structure of the pancreas that produces insulin.
CUBIC requires reagents to fix the tissue so it can not be used in living organisms. However, CUBIC can help people gain insight into the 3D structures of organs and the expression of specific genes in different tissues, said first author Kazuki Tainaka. "Our approach results in almost whole-body, transparent young and adult mice, through which one can observe the cellular networks in the tissue, which is a fundamental challenge in the biological and medical fields."
CUBIC can be used for 3D pathology, anatomy and immunohistochemistry of whole organisms, for example, CUBIC can be used to observe the development of embryos at the cellular level or the development of cancer and autoimmune diseases. The disease process helps us to develop new therapeutic strategies, and whole-body imaging at the single-cell level is expected to bring about the ultimate dream in the field of system biology, "said Hiroki Ueda, a research leader.
The research team is further improving the microscopic imaging method to quickly image the entire body of adult mice and even the human brain. They hope that through this technology, they will have a deep understanding of the mechanisms of autoimmune diseases and mental illnesses.