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广州健仑生物科技有限公司

广州健仑长期供应各种生物原料，主要代理品牌：美国Seracare、西班牙Certest、美国Fuller等等。

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美国Seracare幽门螺旋杆菌阳性对照

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美国Seracare

de Jong称：“这些结果表明，上皮TRPV1通常作为肠道内的一个肿瘤抑制基因。”此外，zui近对人结肠直肠癌样本的分子研究，发现了TRPV1基因中的多个突变，然而Raz指出，目前还没有直接的证据表明，TRPV1缺陷是人类结直肠癌的危险因素。他说：“在今后的临床研究中，应该解决TRPV1功能和人结直肠癌之间的直接关联。”
但是，如果这是事实的话，当前的研究指出，一种潜在的治疗方法可能是辣椒素，它作为哺乳动物的一种刺激物，与组织接触产生一种灼热感。辣椒素已被广泛用作外用药膏的镇痛药，其性质是作为一种压倒神经的刺激物，使神经不能长时间的疼痛。它也是胡椒喷雾剂的活性成分。
研究人员给遗传上更倾向于患多种胃肠道肿瘤的小鼠喂食辣椒素。这种治疗方法导致肿瘤负担减少，使小鼠的寿命延长了超过30%。当联合塞来昔布(celecoxib，一种COX-2非甾体类抗炎药物，已被批准用于治疗一些形式的关节炎和疼痛)使用时，治疗更加有效。
在一个共同合作中，研究人员在纽约州立大学水牛城分校的莫成?帕特尔博士以及劳森健康研究院和加拿大西安大略大学的大卫?希尔博士的带领之下，评估粒线体中的综合酵素--丙酮酸脱氢酶复合体在小鼠新生期间如何调控胰岛的β细胞的发育和成熟。
在胰腺β细胞内葡萄糖的代谢对于胰岛素基因表达和胞外分泌的贺尔蒙来说是很关键的一环，但是有越来越多的证据显示，葡萄糖代谢途径同时对于β-细胞发育和维持成年人的β细胞质量非常重要。在小鼠β细胞中针对葡萄糖激酶剃除后不仅防止了葡萄糖所刺激的胰岛素分泌，而且也抑制了β细胞的增殖，并与细胞凋亡的增加有关联。在组织培养中，直接操纵胚胎胰脏的葡萄糖可用性实验则显示了转录调控因子神经元素3(Neurog3)和NEUROD对于α和β细胞的发育是很必要的存在。
针对此主题，帕特尔等人的论文提到丙酮酸脱氢酶α组件是丙酮酸脱氢酶复合物调控丙酮酸代谢的速率决定酵素;在老鼠实验模式中剔除了β细胞的丙酮酸脱氢酶α组件之后，如同预期的会引起胰岛素可用性降低以及葡萄糖敏感性释放，但是却也同时观察到新生老鼠β细胞数目减少以及Neurog3，NEUROD和的Pdx1的表达。有趣的是，同时也在胰岛素免疫阳性，特胰岛的内分泌小细胞簇中看到数目的减少，意味着也减少了新生β-细胞的来源。这个新发现强调了β-细胞中控制葡萄糖代谢的途径对于维持β-细胞质量以及贺尔蒙和生长因子，例如胰高血糖素样多肽1(GLP1)是同等重要的。

美国Seracare

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、食品安全、化妆品检测、药物滥用检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

"These results show that epithelial TRPV1 is often used as a tumor suppressor in the gut." In addition, a recent molecular study of human colorectal cancer samples revealed multiple mutations in the TRPV1 gene, de Jong said. However, Raz noted that at present There is no direct evidence that TRPV1 deficiency is a risk factor for human colorectal cancer. He said: "In future clinical studies, a direct link between TRPV1 function and human colorectal cancer should be addressed."
However, if this is true, current research suggests that one potential treatment may be capsaicin, a stimulant of mammals that comes into contact with the tissue to create a burning sensation. Capsaicin has been widely used as an analgesic for topical ointments, which act as an overwhelming stimulant that prevents the nerves from prolonged pain. It is also the active ingredient of pepper spray.
Researchers fed caprine to mice genetically more prone to multiple gastrointestinal tumors. This treatment led to reduced tumor burden, extending the lifespan of mice by more than 30%. The treatment is more effective when used in combination with celecoxib (a COX-2 NSAID that has been approved for the treatment of some forms of arthritis and pain).
In a joint effort, researchers under the leadership of Dr. Mo Cheng Pa, of the State University of New York at Buffalo, and Dr. David Hill of the Lawson Health Institute and the University of Western Ontario in Canada, In the synthesis of enzymes - pyruvate dehydrogenase complex in mouse neonatal period how the regulation of islet β cell development and maturation.
Glucose metabolism in pancreatic beta cells is a crucial link to hormonal gene expression and extracellular secretion of hormones, but there is growing evidence that glucose metabolism contributes both to beta-cell development and maintenance of adulthood Human β-cell mass is very important. Shaved for glucokinase in mouse beta cells not only prevents glucose-stimulated insulin secretion but also inhibits beta-cell proliferation and correlates with increased apoptosis. Glucose availability experiments directly manipulating embryonic pancreas in tissue culture showed that the transcriptional regulators Neurog3 and NEUROD are essential for the development of alpha and beta cells.
In response to this topic, Pa et al.'s paper mentions that the pyruvate dehydrogenase alpha component is a pyruvate dehydrogenase complex that regulates the rate-determining enzyme of pyruvate metabolism; the removal of pyruvate from beta cells in experimental models of rats After the hydrogenase α-component, as expected, a decrease in insulin availability and glucose-sensitive release was caused, however, a decrease in the number of β-cells in neonatal mice and the expression of Neurog3, NEUROD and Pdx1 were also observed. Interestingly, a decrease in the number seen also in insulin-immunoreactive, insulinotropic endocrine small cell clusters means that the source of nascent β-cells is also reduced. This new finding emphasizes that the pathways that control glucose metabolism in β-cells are equally important for maintaining β-cell mass and for hormones and growth factors such as glucagon-like polypeptide 1 (GLP1).