癌胚抗原抗体-技术文章-上海博耀生物科技有限公司（上海博耀商贸有限公司）手机版

癌胚抗原抗体

时间：2012-09-11 阅读：3882

Anti-CEA

产品类别产品目录>> 一抗>> 一抗

产品编号by-0719R
英文名称Anti-CEA
中文名称癌胚抗原抗体
别名
CEA ;Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5;
CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100; Ceacam3; Cear; Cgm1;
Cgm4; CGM4AA; MGC114355; RATCEAA; RATCGM4AA.

产品价格0.1ml/100μg/780元0.2ml/200μg/1100元1mg/1mg/3260元

浓度1mg/1ml
抗体来源Rabbit
克隆类型polyclonal
交叉反应hu
产品类型一抗

研究领域肿瘤细胞类型标志物
蛋白分子量predicted molecular weight: 150-200kDa
性状Lyophilized or Liquid
免疫原KLH conjugated synthetic peptide derived from human CEA N-terminus
亚型IgG

纯化方法affinity purified by Protein A
储存液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500
Flow-Cyt=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

保存条件

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody
is stable at room temperature for at least one month and for greater than a year when kept
at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody
is stable for at least two weeks at 2-4 °C.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.

Anti-CEA
产品介绍

CEA-related cell adhesion molecules （CEACAM） belong to the carcinoembryonic antigen （CEA）
family. It consists of seven CEACAM （CEACAM 1, CEACAM 3-CEACAM 8） and 11 pregnancy-specific
glyco-protein （PSG 1-PSG 11） members. The CEA family proteins belong to the immunoglobulin
（Ig） superfamily and are composed of one Ig variable-like （IgV） and a varying number （0-6）
of Ig constant-like （IgC） domains. CEACAM molecules are membrane-bound either via a
transmembrane domain or a glycosyl phosphatidyl inositol （GPI） anchor. CEACAM molecules are
differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM
5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The
function of CEACAM family members varies widely: they function as cell adhesion molecules,
tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of
Neisseria species and other bacteria.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity : Found in adenocarcinomas of endodermally derived digestive system
epithelium and fetal colon.
Similarity : Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like （immunoglobulin-like） domains.
Subunit : Homodimer.

CEA 是一种胚胎性抗原，主要存在于胎儿消化道上皮组织，胰腺和肝癌中。CEA 广泛存在各种上皮性肿
瘤，尤其是胃肠道恶性肿瘤，CEA 分布阳性类型与肿瘤的恶性度有关。CEA 与EMA 一样可作为上皮性恶
性肿瘤的重要标记。