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背景资料

Follicle stimulating hormone （FSH） is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproductionIn women， in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin， which shuts off the FSH production.
In men， FSH enhances the production of androgen-binding proteinby the Sertoli cells of the testes and is critical for spermatogenesis.
In both males and females， FSH stimulates the maturation of germ cells. In females， FSH initiates follicular growth， specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase， there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle.
Like its partner， LH， FSH release at the pituitary gland is controlled by pulses of gonadotropin-releasing hormone（GnRH）. Those pulses， in turn， are subject to the estrogen feed-back from the gonads.

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来源宿主

Urine of post-menopausal women.

溶解建议

提供的人卵泡刺激素产品为白色无菌冻干粉末，冻干粉里不含有其它添加剂.推荐使用无菌的18MΩ的超纯水来溶解，浓度不低于100ug/ml，便于后续稀释.

保存建议

Lyophilized FSH although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution FSH-beta should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。  生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。