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mouse Anti-VEGF抗体，VEGF抗体说明书 antibody
Catalog Number : RS-1665R
Quantity size : 100ul (dilute with pH 7.4 0.01 M PBS or antibody diluent )
background:
This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that
specifically acts on endothelial cells and has various effects, including mediating increased
vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting
cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. Also, alternative translation initiation from non-AUG
(CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided
by RefSeq].
Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces
endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces
permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors,
heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not
activate angiogenesis and inhibits tumor growth.
Subunit:
Homodimer; disulfide-linked. Also found as heterodimer with PGF
Specificity : Anti-VEGF is a mouse monoclonal antibody
specific for anti-VEGF of Dog,human,mouse, Rat
- use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 24kDa
Application :
– WB=1:100-500
– ELISA=1:500-1000
– IHC-P=1:100-500
– IHC-F=1:100-500
– optimal dilutions/concentrations should be determined by the end user..
KLH conjugated synthetic peptide derived from human VEGF
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized
antibody is stable at room temperature for at least one month and for greater than a year
when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody,
the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in
human, therapeutic or diagnostic applications.