Anti- PPARGC1A/PGC1 alpha抗体说明书现货价格

Catalog Number :RS-1832R

Quantity size :   0.1ml  （dilute with pH 7.4    0.01 M PBS or antibody diluent ） Background: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein （CREB） and nuclear respiratory factors （NRFs）. It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity （referenced from entrez gene.
Subunit : Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with PRDM16. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1.
Subcellular Location : Nucleus.
Tissue Specificity : Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
Similarity : Contains 1 RRM （RNA recognition motif） domain.
Database links :PPARGC1A/PGC1 alpha抗体说明书

Specificity : Anti-PPARGC1A/PGC1 alpha is a rabbit  polyclonal antibody               specificforPPARGC1A/PGC1 alphaof Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

use for western blotting,elisa,immunoprecipitation and immunohistochemistry

• Protein G affinity chromatography purification, purity :>95%
• Isotype:  IgG 
• mol wt:  88kDa
• Application :   PPARGC1A/PGC1 alpha抗体说明书
• WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 KLH conjugated synthetic peptide derived from human PGC-1 631-680aa
• not yet tested in other applications.
• optimal dilutions/concentrations should be determined by the end user..

Storage:  Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The  lyophilized antibody is stable at room temperature for at least one month and for greater  than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent  of antibody, the antibody is stable for at least six weeks at 2-4 ℃

Important Note: This product as supplied is intended for research use only, not for use in  human, therapeutic or diagnostic applications.