Rabbit Anti-SNAI抗体*
Catalog Number :HZ390650 Quantity size : 0.1ml (dilute with pH 7.4
0.01 M PBS or antibody diluent )
Background: The Snail family of developmental regulatory proteins is a group of
widely conserved zinc-finger proteins that regulate transcription and include the
mammalian proteins SLUG; SNAI 1, the human homolog of Drosophila SNAIL; and
Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal
muscle. SNAI 1 and the corresponding mouse homolog, Sna, each contain three
classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger
regions and a transcriptional repression domain at the amino-terminus, which enables
SLUG to act as a negative regulator of gene expression. SLUG is implicated in the
generation and migration of neural crest cells in human embryos and also contributes
to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic
transcription factor that effectively prevents apoptosis in murine pro-B cells deprived
of IL-3. The SNAIL-related gene from murine skeletal muscle cells, Smuc, is highly
expressed in skeletal muscle and thymus and can, likewise, repress gene
transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box
motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger
domains at the C-terminal region of Smuc.
specificity :
Rabbit Anti-SNAI抗体*
– Anti- SNAI is a rabbit polyclonal antibody unconjugated
– specific for SNAI of human, mouse and rat
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 29kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. The
lyophilized antibody is stable at room temperature for at least one month and for
greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M
PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for
use in human, therapeutic or diagnostic applications.Rabbit Anti-SNAI抗体*